Erythropoietin

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Erythropoietin Structure, Function, and History

Human erythropoietin NMR structure (PDB code 1buy).

3D structures of erythropoietin

Updated on 11-December-2019

1cn4 – hEP (mutant) + EP receptor – human
1buy – hEP (mutant) - NMR
1eer – hEP (mutant) + EP receptor (mutant)

References


  1. Kawakita M, Ogawa M, Goldwasser E, Miyake T. Characterization of human megakaryocyte colony-stimulating factor in the urinary extracts from patients with aplastic anemia and idiopathic thrombocytopenic purpura. Blood. 1983 Mar;61(3):556-60. PMID:6600633
  2. Jelkmann W. Erythropoietin after a century of research: younger than ever. Eur J Haematol. 2007 Mar;78(3):183-205. Epub 2007 Jan 23. PMID:17253966 doi:http://dx.doi.org/10.1111/j.1600-0609.2007.00818.x
  3. Jelkmann W. Erythropoietin after a century of research: younger than ever. Eur J Haematol. 2007 Mar;78(3):183-205. Epub 2007 Jan 23. PMID:17253966 doi:http://dx.doi.org/10.1111/j.1600-0609.2007.00818.x
  4. Jelkmann W. Erythropoietin: structure, control of production, and function. Physiol Rev. 1992 Apr;72(2):449-89. PMID:1557429
  5. Jelkmann W. Erythropoietin after a century of research: younger than ever. Eur J Haematol. 2007 Mar;78(3):183-205. Epub 2007 Jan 23. PMID:17253966 doi:http://dx.doi.org/10.1111/j.1600-0609.2007.00818.x
  6. Erslev, A. J., and J. Caro. "Physiologic and molecular biology of erythropoietin." Medical oncology and tumor pharmacotherapy 3.3-4 (1986): 159-164.
  7. Erslev, A. J., and J. Caro. "Physiologic and molecular biology of erythropoietin." Medical oncology and tumor pharmacotherapy 3.3-4 (1986): 159-164.
  8. Erslev, A. J., and J. Caro. "Physiologic and molecular biology of erythropoietin." Medical oncology and tumor pharmacotherapy 3.3-4 (1986): 159-164.
  9. Jelkmann W. Erythropoietin after a century of research: younger than ever. Eur J Haematol. 2007 Mar;78(3):183-205. Epub 2007 Jan 23. PMID:17253966 doi:http://dx.doi.org/10.1111/j.1600-0609.2007.00818.x
  10. Constantinescu, Stefan N., Saghi Ghaffar, Harvey F. Lodish. The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends in Endocrinology and Metabolism, Volume10, Issue 1, 1January 1999, Pages 18-23.
  11. Constantinescu, Stefan N., Saghi Ghaffar, Harvey F. Lodish. The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends in Endocrinology and Metabolism, Volume10, Issue 1, 1January 1999, Pages 18-23.
  12. Constantinescu, Stefan N., Saghi Ghaffar, Harvey F. Lodish. The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends in Endocrinology and Metabolism, Volume10, Issue 1, 1January 1999, Pages 18-23.
  13. Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998 Oct 1;395(6701):511-6. PMID:9774108 doi:http://dx.doi.org/10.1038/26773
  14. Constantinescu, Stefan N., Saghi Ghaffar, Harvey F. Lodish. The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction. Trends in Endocrinology and Metabolism, Volume10, Issue 1, 1January 1999, Pages 18-23.

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