Factor VIIa

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Human factor VIIa heavy chain (pink) and light chain (cyan) complex with soluble tissue factor (dark red, dark green) and a peptide inhibitor, cacodylate, Cl- and Ca+2 ions 1dan

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Additional Resources

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References

  1. Pike AC, Brzozowski AM, Roberts SM, Olsen OH, Persson E. Structure of human factor VIIa and its implications for the triggering of blood coagulation. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8925-30. PMID:10430872
  2. Bajaj SP, Rapaport SI, Brown SF. Isolation and characterization of human factor VII. Activation of factor VII by factor Xa. J Biol Chem. 1981 Jan 10;256(1):253-9. PMID:6778860
  3. Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature. 1996 Mar 7;380(6569):41-6. PMID:8598903 doi:http://dx.doi.org/10.1038/380041a0
  4. Lawson JH, Butenas S, Mann KG. The evaluation of complex-dependent alterations in human factor VIIa. J Biol Chem. 1992 Mar 5;267(7):4834-43. PMID:1537862
  5. Bjelke JR, Olsen OH, Fodje M, Svensson LA, Bang S, Bolt G, Kragelund BB, Persson E. Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity. J Biol Chem. 2008 Sep 19;283(38):25863-70. Epub 2008 Jul 17. PMID:18640965 doi:10.1074/jbc.M800841200
  6. Freskgard PO, Olsen OH, Persson E. Structural changes in factor VIIa induced by Ca2+ and tissue factor studied using circular dichroism spectroscopy. Protein Sci. 1996 Aug;5(8):1531-40. PMID:8844844 doi:10.1002/pro.5560050809
  7. Bajaj SP, Schmidt AE, Agah S, Bajaj MS, Padmanabhan K. High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa. J Biol Chem. 2006 Aug 25;281(34):24873-88. Epub 2006 Jun 6. PMID:16757484 doi:10.1074/jbc.M509971200
  8. Hedstrom L. Serine protease mechanism and specificity. Chem Rev. 2002 Dec;102(12):4501-24. PMID:12475199
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  10. Ash EL, Sudmeier JL, De Fabo EC, Bachovchin WW. A low-barrier hydrogen bond in the catalytic triad of serine proteases? Theory versus experiment. Science. 1997 Nov 7;278(5340):1128-32. PMID:9353195
  11. Bachovchin WW. 15N NMR spectroscopy of hydrogen-bonding interactions in the active site of serine proteases: evidence for a moving histidine mechanism. Biochemistry. 1986 Nov 18;25(23):7751-9. PMID:3542033
  12. Fedorov A, Shi W, Kicska G, Fedorov E, Tyler PC, Furneaux RH, Hanson JC, Gainsford GJ, Larese JZ, Schramm VL, Almo SC. Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis. Biochemistry. 2001 Jan 30;40(4):853-60. PMID:11170405
  13. Polgar L. Transition state stabilization and enzymic rate acceleration. Acta Biochim Biophys Hung. 1989;24(1-2):25-32. PMID:2514538
  14. Bajaj SP, Schmidt AE, Agah S, Bajaj MS, Padmanabhan K. High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa. J Biol Chem. 2006 Aug 25;281(34):24873-88. Epub 2006 Jun 6. PMID:16757484 doi:10.1074/jbc.M509971200
  15. Perona JJ, Craik CS. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold. J Biol Chem. 1997 Nov 28;272(48):29987-90. PMID:9374470
  16. Bone R, Silen JL, Agard DA. Structural plasticity broadens the specificity of an engineered protease. Nature. 1989 May 18;339(6221):191-5. PMID:2716847 doi:http://dx.doi.org/10.1038/339191a0
  17. Ohwaki K, Hungate RE. Hydrogen utilization by clostridia in sewage sludge. Appl Environ Microbiol. 1977 Jun;33(6):1270-4. PMID:879782

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