From Proteopedia

Jump to: navigation, search

Synthetic gliadin peptide (cyan) complex with HLA class II histocompatibility antigen (α chain in magenta, β chain in green) and ethylene glycol (PDB code 1s9v)

3D structures of gliadin

Updated on 07-April-2020

4gg6 – wGLI alpha/beta peptide + antibody + T-cell receptor – wheat
4z7u, 4z7v, 4z7w – wGLI alpha-1 peptide + antibody + T-cell receptor
4ozf, 4ozg, 4ozh, 4ozi – wGLI alpha-2 peptide + antibody + T-cell receptor
1s9v, 2nna – GLI alpha-1 peptide + antibody - synthetic
4d8p – wGLI gamma peptide + antibody


  1. Celiac Disease: MedlinePlus. Retrieved October 27, 2015, from
  2. Celiac Disease. Retrieved October 27, 2015, from
  3. Go to Science. Retrieved October 27, 2015, from
  4. 4.0 4.1 Maiuri, L., Ciacci, C., Ricciardelli, I., Vacca, L., Raia, V., Auricchio, S., . . . Londei, M. (2003). Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet, 362(9377), 30-37. doi:10.1016/S0140-6736(03)13803-2
  5. Mellins, E., & Stern, L. (n.d.). HLA-DM and HLA-DO, key regulators of MHC-ll processing and presentation. Current Opinion in Immunology, 26, 115-122. February 2014.
  6. Kim, C., Quartsen, H., Bergsen, E., Khosla, C., & Sollid, L.. (n.d.). Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Cross Mark, 101(12), 4175-4179. March 2004
  7. Henderson, K. N., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N. A., Beissbarth, T., . . . Anderson, R. P. (2007). A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease. Immunity,27(1), 23-34. doi:10.1016/j.immuni.2007.05.015
  8. 8.0 8.1 8.2 8.3 8.4 Shan, L., I. I. Mathews, and C. Khosla. "Structural and Mechanistic Analysis of Two Prolyl nEndopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity." Proceedings of the National Academy of Sciences 102.10 (2005): 3599-604. Web.
  9. 9.0 9.1 "Permission is not required to use original figures or tables for noncommercial and educational use",Rights & Permissions, Proceedings of the National Aademy of Sciences, USA.
  10. Matysiak-Budnik, T., Candalh, C., Cellier, C., Dugave, C., Namane, A., Vidal-Martinez, T., . . . Heyman, M. (2005). Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease. Gastroenterology,129(3), 786-796. doi:10.1053/j.gastro.2005.06.016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Premal Patel, Eric Martz, Alexander Berchansky, Devin Joseph, Ben Horansky, Gunnar Reiske, Katlin Cannon, Joel L. Sussman, Jaime Prilusky

Personal tools