Gluten

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Synthetic gliadin peptide (cyan) complex with HLA class II histocompatibility antigen (α chain in magenta, β chain in green) and ethylene glycol (PDB code 1s9v)

3D structures of gliadin

Updated on 20-October-2017

4gg6 – wGLI alpha/beta peptide + antibody + T-cell receptor – wheat
4z7u, 4z7v, 4z7w – wGLI alpha-1 peptide + antibody + T-cell receptor
4ozf, 4ozg, 4ozh, 4ozi – wGLI alpha-2 peptide + antibody + T-cell receptor
1s9v, 2nna – GLI alpha-1 peptide + antibody - synthetic
4d8p – wGLI gamma peptide + antibody

References

  1. Celiac Disease: MedlinePlus. Retrieved October 27, 2015, from https://www.nlm.nih.gov/medlineplus/celiacdisease.html
  2. Celiac Disease. Retrieved October 27, 2015, from http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/celiac-disease/Pages/facts.aspx
  3. Go to Science. Retrieved October 27, 2015, from http://www.sciencemag.org/content/297/5590/2275.full
  4. 4.0 4.1 Maiuri, L., Ciacci, C., Ricciardelli, I., Vacca, L., Raia, V., Auricchio, S., . . . Londei, M. (2003). Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet, 362(9377), 30-37. doi:10.1016/S0140-6736(03)13803-2
  5. Mellins, E., & Stern, L. (n.d.). HLA-DM and HLA-DO, key regulators of MHC-ll processing and presentation. Current Opinion in Immunology, 26, 115-122. February 2014. http://www.sciencedirect.com/science/article/pii/S095279151300215X
  6. Kim, C., Quartsen, H., Bergsen, E., Khosla, C., & Sollid, L.. (n.d.). Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Cross Mark, 101(12), 4175-4179. March 2004 http://www.pnas.org/content/101/12/4175.figures-only
  7. Henderson, K. N., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N. A., Beissbarth, T., . . . Anderson, R. P. (2007). A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease. Immunity,27(1), 23-34. doi:10.1016/j.immuni.2007.05.015
  8. 8.0 8.1 8.2 8.3 8.4 Shan, L., I. I. Mathews, and C. Khosla. "Structural and Mechanistic Analysis of Two Prolyl nEndopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity." Proceedings of the National Academy of Sciences 102.10 (2005): 3599-604. Web.
  9. Matysiak-Budnik, T., Candalh, C., Cellier, C., Dugave, C., Namane, A., Vidal-Martinez, T., . . . Heyman, M. (2005). Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease. Gastroenterology,129(3), 786-796. doi:10.1053/j.gastro.2005.06.016

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