Gp41

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Function

Gp41 is a subunit of the envelope protein of retrovirus[1]. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see HIV-1 viral envelope proteins.

Relevance

Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell[2].

3D Structures of Gp41

Gp41 3D Structures


Core structure of acetylated gp41 from the HIV envelope glycoprotein, 1aik.

Drag the structure with the mouse to rotate

References

  1. Chan DC, Kim PS. HIV entry and its inhibition. Cell. 1998 May 29;93(5):681-4. PMID:9630213
  2. Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Curr Pharm Des. 2004;10(15):1805-25. PMID:15180542

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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