Function
Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains.
- GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction[1].
- GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway[2].
- GRB10 and GRB14 interact with insulin receptor and insulin-like growth factor receptors[3]. For additional details on GRB10 see Grb10 SH2 Domain.
Structural highlights
Human GRB2 residue into a turn conformation. Water molecules are shown as red spheres. [4].
3D structures of growth factor receptor-bound proteins
Growth factor receptor-bound proteins 3D structures