Hexokinase Type 1

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PDB ID 1cza

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  1. Cummings R., Esko J., Freeze H., Hart G., Marth J., Varki A. Essentials of Glycobiology. 2nd Edition. Consortium of Glycobiology. 1999. 203
  2. 2.0 2.1 2.2 2.3 Aleshin A., Bartunik G., Bourenkov G., Fromm H., Hozatko R., Kirby C., Liu X. Crystal structures of monomeric hexokinase type I reveal ADP binding site and conformational changes relevant to allosteric regulation. The Journal of Molecular Biology. 2002. 294: 1001-1015. PMID 10686099
  3. Henningsen C., Thaiss F., Zahner G. High glucose induces type I hexokinase gene expression in isolated glomeruli of diabetic rats and in mesangial cells. Nephron Physiology. 2003.93:67-75.
  4. 4.0 4.1 4.2 4.3 4.4 Garavito R., Mulichuk A., Padmanabhan K., Wilson J. The structure of mammalian hexokinase-1. Nature Structural and Molecular Biology. 1998. 5: 555-560.
  5. Fromm H., Zewe V. Kinetic studies of the brain hexokinase reaction. The Journal of Biological Chemistry. 1962.235:1661-1667.
  6. Bianchi M., Bolognesi M., Deriu D., Magnani M., Murshudov G., Rizzi M., Rosano C., Sabini E., Serafini G. Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control. Structure. 1999. 11: 1427-1437. PMID 10574795
  7. Hay N., Robey R. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene. 2006. 25: 4683-4696.
  8. Martin D., Huang P., Pelicano H., Xu R. Glycolysis inhibition for anticancer treatment. Oncogene. 2006. 25: 4633-4646.
  9. Bianchi M., Casabianca A., Magnani M., Serafini G., Stocchi V. Human hexokinase type I microheterogeneity is due to different amino-terminal sequences. The Journal of Biological Chemistry. 1991. 266: 502-505.
  10. Wilson, J. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. The Journal of Experimental Biology. 2003.206:2049-2057.
  11. Garavito R., Mulichak A., Sebastian S., Wilson J. Allosteric Regulation of Type I Hexokinase: A Site-Directed Mutational Study Indicating Location of the Functional Glucose-6-Phosphate Binding Site in the N-terminal Half of the Enzyme. Archives of Biochemistry and Biophysics. 1999. 15: 203-210.

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