Horse Liver Alcohol Dehydrogenase

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Horse liver alcohol dehydrogenase complex with Zn+2 ion (grey) and ribofuranosylpicolinamide adenine dinucleotide (PDB code 1a72)

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3D structures of horse liver alcohol dehydrogenase

Alcohol dehydrogenase


  1. 1.0 1.1 1.2 1.3 1.4 1.5 Ramaswamy S, Eklund H, Plapp BV. Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols. Biochemistry. 1994 May 3;33(17):5230-7. PMID:8172897
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Bahnson BJ, Colby TD, Chin JK, Goldstein BM, Klinman JP. A link between protein structure and enzyme catalyzed hydrogen tunneling. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12797-802. PMID:9371755
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM. Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes. Biochemistry. 1998 Jun 30;37(26):9295-304. PMID:9649310 doi:10.1021/bi973184b
  4. 4.0 4.1 4.2 4.3 4.4 Bahnson BJ, Park DH, Kim K, Plapp BV, Klinman JP. Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site-directed mutagenesis. Biochemistry. 1993 Jun 1;32(21):5503-7. PMID:8504071
  5. 5.0 5.1 5.2 Eklund H, Nordstrom B, Zeppezauer E, Soderlund G, Ohlsson I, Boiwe T, Soderberg BO, Tapia O, Branden CI, Akeson A. Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution. J Mol Biol. 1976 Mar 25;102(1):27-59. PMID:178875
  6. 6.0 6.1 6.2 Brandt EG, Hellgren M, Brinck T, Bergman T, Edholm O. Molecular dynamics study of zinc binding to cysteines in a peptide mimic of the alcohol dehydrogenase structural zinc site. Phys Chem Chem Phys. 2009 Feb 14;11(6):975-83. Epub 2008 Dec 12. PMID:19177216 doi:10.1039/b815482a
  7. Olson LP, Luo J, Almarsson O, Bruice TC. Mechanism of aldehyde oxidation catalyzed by horse liver alcohol dehydrogenase. Biochemistry. 1996 Jul 30;35(30):9782-91. PMID:8703951 doi:10.1021/bi952020x

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