Human growth hormone

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Human growth hormone and the extracellular domain of its receptor (PDB entry 3hhr)

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3D structures of human growth hormone

Updated on 09-July-2023
3hhr - HGH + extracellular domain of its receptor
1huw, 1hgu – HGH – human
3hhr, 1hwg, 1kf9 – HGH + HGH receptor
1hwh, 1a22 – HGH (mutant) + HGH receptor
1axi – HGH (mutant) + HGH receptor (mutant)
1bp3 – HGH (mutant) + prolactin receptor


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  8. Miller TL, Mayo KE. Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression. Endocrinology. 1997 Jun;138(6):2458-65. PMID:9165036 doi:
  9. Lima L, Arce V, Diaz MJ, Tresguerres JA, Devesa J. Glucocorticoids may inhibit growth hormone release by enhancing beta-adrenergic responsiveness in hypothalamic somatostatin neurons. J Clin Endocrinol Metab. 1993 Feb;76(2):439-44. PMID:8094392 doi:
  10. Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest. 2004 Jan;113(1):96-105. PMID:14702113 doi:
  11. Freda PU, Post KD, Powell JS, Wardlaw SL. Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly. J Clin Endocrinol Metab. 1998 Nov;83(11):3808-16. PMID:9814451 doi:

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