Insulin-Degrading Enzyme

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Human insulin-degrading enzyme (grey and green) complex with glucagon preproprotein peptide (pink and yellow) and diethylene dioxide (PDB code 2g49)

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  • Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5. PMID:17613531 doi:10.1074/jbc.M701590200
  • Shen Y, Joachimiak A, Rosner MR, Tang WJ. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19;443(7113):870-4. Epub 2006 Oct 11. PMID:17051221 doi:10.1038/nature05143
  • Li P, Kuo WL, Yousef M, Rosner MR, Tang WJ. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochem Biophys Res Commun. 2006 May 19;343(4):1032-7. Epub 2006 Mar 22. PMID:16574064 doi:10.1016/j.bbrc.2006.03.083
  1. Chen KC, Chang SS, Tsai FJ, Chen CY. Han ethnicity-specific type 2 diabetic treatment from traditional Chinese medicine? J Biomol Struct Dyn. 2012 Nov 12. PMID:23146021 doi:10.1080/07391102.2012.732340
  2. Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One. 2010 May 7;5(5):e10504. PMID:20498699 doi:10.1371/journal.pone.0010504
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