Listeriolysin positive regulatory factor A

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Listeria monocytogenes listeriolysin positive regulatory factor A complex with DNA and glutathione (PDB code5lrs)

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3D structures of listeriolysin positive regulatory factor A

1omi - LmPrfA - Listeria monocytogenes
6qw2, 5qvz, 6qw1, 2bgc, 6qvy - LmPrfA (mutant)
5x6d, 5lej - LmPrfA + DNA
6qwm, 6qwf, 6qwh, 6qwk, 5lek - LmPrfA (mutant) + DNA
5lrr - LmPrfA + glutathione
5x6e, 5lrs - LmPrfA + DNA + glutathione
2beo - LmPrfA (mutant) + Gln
6euz, 6euu, 6exl, 6exm, 6ev0, 6eut, 6exk, 5f1r - LmPrfA + inhibitor
6hck - LmPrfA + dipeptide


  1. Hansen S, Hall M, Grundstrom C, Brannstrom K, Sauer-Eriksson AE, Johansson J. A novel growth based selection strategy identifies new constitutively active variants of the major virulence regulator PrfA in Listeria monocytogenes. J Bacteriol. 2020 Mar 16. pii: JB.00115-20. doi: 10.1128/JB.00115-20. PMID:32179627 doi:
  2. Sternkopf Lillebaek EM, Lambert Nielsen S, Scheel Thomasen R, Faergeman NJ, Kallipolitis BH. Antimicrobial medium- and long-chain free fatty acids prevent PrfA-dependent activation of virulence genes in Listeria monocytogenes. Res Microbiol. 2017 Jul - Aug;168(6):547-557. doi: 10.1016/j.resmic.2017.03.002. , Epub 2017 Mar 23. PMID:28344104 doi:

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