MAP kinase phosphatase

From Proteopedia

spinqualitylabelsall models MAP kinase phosphatase 3 (PDB code 1hzm) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function MAP kinase phosphatase (MKP) or Dual specificity phosphatase (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues[1]. MKP-2 is essential in protection against intracellular infection[2]. MKP-3 is localized in the nucleus and dephosphorylates phosphoTyr in p38a[3]. MKP-4 is localized in the nucleus and cytosole MKP-5 is localized in the nucleus and cytosole and is involved in pressure overload-induced cardiac fibrosis[4]. MKP-6, MKP-7 are localized in the nucleus Relevance DUSP is implicated in the initiation and development of cancer[5].

3D Structures of MAP kinase phosphatase

Updated on 11-July-2024

3ezz – hMKP-2 (mutant) or DUSP-HVH2 - human
2hcm – mDUSP
1m3g – hMKP-PAC-1 catalytic domain (mutant) - NMR
2g6z – hMKP-3
1hzm - hMKP-3 or DUSP-5
1mkp - hMKP-3 or DUSP-5 (mutant)
3lj8 – hMKP-4
4jmk – hDUSP-8 (mutant)
2ouc, 2oud, 1zzw, 7y4c - hMKP-5 or DUSP-10
7y4b, 7y4d, 7y4e – hMKP-5 (mutant)
6mc1, 7u4o, 7u4r, 7umu, 7umv, 7un0, 7un4 – hMKP-5 + inhibitor
3tg1 – hMKP-5 + MAP kinase 14
4jmj – hDUSP-11 catalytic domain (mutant)
2wgp – hMKP-6 or DUSP-14
1yz4 – hDUSP-15 catalytic domain (mutant)
2vsw, 3tg3 - hMKP-7 or DUSP-16
4yr8 – hMKP-7 + MAPK8
4d3p, 4d3q, 4d3r – hDUSP-19 (mutant)
4woh – hDUSP-22 (mutant) + nitrophenolphosphate
2img – hDUSP-23 + malate
5gtj, 4b04, 4hrf – hDUSP-26 catalytic domain (mutant)

References

1. ↑ Boutros T, Chevet E, Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008 Sep;60(3):261-310. doi: 10.1124/pr.107.00106. PMID:18922965 doi:http://dx.doi.org/10.1124/pr.107.00106
2. ↑ Al-Mutairi MS, Cadalbert LC, McGachy HA, Shweash M, Schroeder J, Kurnik M, Sloss CM, Bryant CE, Alexander J, Plevin R. MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. PLoS Pathog. 2010 Nov 11;6(11):e1001192. PMID:21085614 doi:10.1371/journal.ppat.1001192
3. ↑ Zhang YY, Wu JW, Wang ZX. Mitogen-activated Protein Kinase (MAPK) Phosphatase 3-mediated Cross-talk between MAPKs ERK2 and p38{alpha}. J Biol Chem. 2011 May 6;286(18):16150-62. Epub 2011 Mar 16. PMID:21454500 doi:10.1074/jbc.M110.203786
4. ↑ Zhong C, Min K, Zhao Z, Zhang C, Gao E, Huang Y, Zhang X, Baldini M, Roy R, Yang X, Koch WJ, Bennett AM, Yu J. MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. Front Immunol. 2021 Dec 21;12:790511. PMID:34992607 doi:10.3389/fimmu.2021.790511
5. ↑ Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 2008 Jun;27(2):253-61. doi: 10.1007/s10555-008-9123-1. PMID:18330678 doi:http://dx.doi.org/10.1007/s10555-008-9123-1