Function
Methylesterase (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways.
- CheB ME is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors[1]. See Chemotaxis protein.
- Pectin ME causes demethylation of cell wall polygalactorunanas. It is involved in pectin digestion. The reaction products liberate frothing agents causing bloating in cattle[2].
- Aclacinomycin ME modifies the aklavinone skeleton in the biosynthesis of anthracyclins in Streptomyces species[3].
- Protein phosphatase ME is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation[4].
- 4-o-methyl-glucuronoyl ME has a significant role in biomass degradation[5].
Structural highlights
- .
- . It inactivates phospholipase 2A by interacting with the latter's subunit C by removing two catalytic Mn+2 ions from it[6].
3D structures of methylesterase
Methylesterase 3D structures