Mevalonate pathway

Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins.

Acetyl-CoA is coming from Citric Acid Cycle.

Mevalonate pathway

Acetoacetyl-CoA thiolase

• Acetoacetyl-CoA thiolase

Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10

• 1xpk

HMG-CoA Reductase

• HMG-CoA Reductase

Mevalonate kinase

• Mevalonate kinase

Phosphomevalonate kinase

• The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution 3ch4

Mevalonate-5-pyrophosphate decarboxylase

Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase.

• Mevalonate Diphosphate Decarboxylase

Isopentenyl pyrophosphate isomerase

Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase

• Isopentenyl-diphosphate delta-isomerase

Mevalonate is finally converted to isopentenyl pyrophosphate.