NEDD8

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NEDD8 is a ubiquitin-like protein in humans. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase[1]. In yeast the protein is called Rub1.

  • Cl coordination site is located between 2 monomers. Water molecules are shown as red spheres.

Human NEDD8 complex with sulfate and Cl- (green) ions, 1ndd

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3D Structures of NEDD8

Updated on 17-November-2021

NEDD8
NEDD8+ubiquitin-activating enzyme E1
NEDD8+other proteins
Rub1

References

  1. ↑ Chiba T, Tanaka K. Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system. Curr Protein Pept Sci. 2004 Jun;5(3):177-84. PMID:15180522

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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