Nuclear receptor coactivator

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Mouse nuclear receptor activator (green) complex with STAT6 transactivator domain LXXLL peptide (sky blue) and I-1 ions, 1oj5

3D structures of nuclear receptor coactivator

1v95 – hNCOA5 anticodon binding domain 197-313 – human - NMR
1kbh – hNCOA 1040-1086 + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide - mouse
5y7w - mNCOA1A Pas-B domain + YL-2 peptide


  1. Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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