Period circadian protein

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Mouse PER2 homolog Cry domain (green) complex with cryptochrome-1 (deep sky blue), PEG400, Cl- (green) and Zn+2 (grey) ions (PDB code 4ct0)

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3D Structures of period circadian protein

Updated on 22-August-2023

6of7 – hPER2 residues 1093-1212 + cryptochrome-1 – human
4dj2 – mPER1 homolog Cry domain – mouse
4ct0 – mPER2 homolog Cry domain + cryptochrome-1
4u8h – mPER2 homolog Cry domain + cryptochrome-2
3gdi – mPER2 homolog PAS domain
4dj3 – mPER3 homolog residues 108-411
3rty, 1wa9, 3gec – PER PAS domain – Drosophila melanogaster


  1. Chen ST, Choo KB, Hou MF, Yeh KT, Kuo SJ, Chang JG. Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis. 2005 Jul;26(7):1241-6. Epub 2005 Mar 24. PMID:15790588 doi:
  2. Schmalen I, Reischl S, Wallach T, Klemz R, Grudziecki A, Prabu JR, Benda C, Kramer A, Wolf E. Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation. Cell. 2014 May 22;157(5):1203-15. doi: 10.1016/j.cell.2014.03.057. PMID:24855952 doi:

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