Phage integrase

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Phage integrase (PIN) mediates recombination between DNA recognition sequences - the phage attachment site attP and the bacterial attachment site attB[1]. The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.

  • The biological assembly of Enterobacteria phage λ integrase is homotetramer.

Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) 1z1g

Drag the structure with the mouse to rotate

3D Structures of phage integrase see Retroviral Integrase

References

  1. ↑ Groth AC, Calos MP. Phage integrases: biology and applications. J Mol Biol. 2004 Jan 16;335(3):667-78. PMID:14687564 doi:http://dx.doi.org/10.1016/S0022283603013561

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