Retroviral Integrase

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N-terminal and core domain of HIV-1 integrase complex with phosphate, Zn+2 (grey) and K+ (purple) ions (PDB code 1k6y)

References

  1. Pandey KK, Grandgenett DP. HIV-1 Integrase Strand Transfer Inhibitors: Novel Insights into their Mechanism of Action. Retrovirology (Auckl). 2008 Nov 5;2:11-16. PMID:19915684
  2. 2.0 2.1 2.2 2.3 Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature. 2010 Mar 11;464(7286):232-6. Epub 2010 Jan 31. PMID:20118915 doi:10.1038/nature08784
  3. deJesus, Edwin HIV Antiretroviral Agents in Development. The Body: The Complete HIV/AIDS Resource. March 30, 2006
  4. Braun, J.F., Cronje, R.J and Henderson, M.G. HIV-1 Integrase Inhibitors Inhibitors (2008). www.prn.org Volume 13, Pages 1–9
  5. AIDS-Info
  6. Iwamoto M, Wenning LA, Petry AS, Laethem M, De Smet M, Kost JT, Breidinger SA, Mangin EC, Azrolan N, Greenberg HE, Haazen W, Stone JA, Gottesdiener KM, Wagner JA. Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Antimicrob Agents Chemother. 2008 Dec;52(12):4338-43. Epub 2008 Oct 6. PMID:18838589 doi:10.1128/AAC.01543-07

Further Reading

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