Function
Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing[1].
- Prp3b is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)
- Prp8 functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see Prp8
- Prp18 and Bud31 are essential for the catalytic step in pre-mRNA splicing process.
- snRNA-associated-splicing factor 24 binds preferentially to the U4/U6 hybrid snRNAs. For details see Prp24
- For Prp19 see Prp19
- For Prp20 see Srp20-Human Alternative Splicing Factor
- Prp31 functions in forming the U4/U5-U6 tri-snRNP.
- For Prp40 see Prp40.
- Prpcwc2 is a yeast splicing factor which plays a role in the generation of a functional splicing center Prp RBM22 is the human homolog of Prpcwc2.
- Prpcwc26 or Bud13 belongs to the pre-mRNA retention and splicing complex RES.
Disease
Mutations in Prp8 and Prp31 cause retinitis pigmentosa[2].
Structural highlights
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3D Structures of pre-mRNA splicing factors
Pre-mRNA splicing factors 3D structures
