Prostaglandin E synthase

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Human PGES complex with inhibitor and glutathione (PDB code 4yl0)

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3D Structures of prostaglandin E synthase

Updated on 13-September-2023

3dww, 4al0, 4wab, 4bpm – hPGES-1 + glutathione – human
4al1 – hPGES-1 + glutathione analog
6vl4 – hPGES-1 + inhibitor
5bqg, 5bqh, 5bqi, 5k0i, 5t36, 5t37, 5tl9, 4yk5, 4yl0, 4yl1, 4yl3 – hPGES-1 + glutathione + inhibitor
7l7j – hPGES-3 + Hsp90 – Cryo EM
7l7i – hPGES-3 + Hsp90 + FKBP5 – Cryo EM
7krj – hPGES-3 + Hsp90 + glucocorticoid receptor – Cryo EM
1z9h – MaPGES-2 + indomethacin – Macaque
2pbj – MaPGES-2 + heme + glutathione
7y04 – mPGES-3 + Hsp90 + AHR - mouse – Cryo EM
8h77 – mPGES-3 + Hsp90 + AHR + AHR-interacting protein – Cryo EM


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  2. Kudo I, Murakami M. Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis. J Biochem Mol Biol. 2005 Nov 30;38(6):633-8. PMID:16336776
  3. Murakami M, Kudo I. Prostaglandin E synthase: a novel drug target for inflammation and cancer. Curr Pharm Des. 2006;12(8):943-54. PMID:16533161
  4. Luz JG, Antonysamy S, Kuklish SL, Condon B, Lee MR, Allison D, Yu XP, Chandrasekhar S, Backer R, Zhang A, Russell M, Chang SS, Harvey A, Sloan AV, Fisher MJ. Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. J Med Chem. 2015 May 20. PMID:25961169 doi:

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