Function
Protein DJ-1 or DJ-1 or PARK7 or protein/nucleic acid deglycase DJ-1 or protein deglycase DJ-1 or RNA-binding protein regulatory subunit is a cancer- and Parkinson Disease-associated protein which protects cells from toxic stresses. Dj-1 is an antioxidant and functions in transcription modulatory activity[1].
Disease
The loss of DJ-1 leads to deficits in the detoxification enzyme NADP-quinone oxidoreductase[2]. Mutations in DJ-1 caused early onset of Parkinson disease[3].
Structural highlights
The 3D structure of DJ-1 complex with the inhibitor isatin shows the covalent bond formed between isatin and DJ-1 as well as the between the inhibitor and the protein[4]. . Water molecules are shown as red spheres.
3D structures of protein DJ-1
Updated on 14-September-2023
3sf8, 6m8z, 4bte, 4p34, 4p35, 4p36, 4p2g, 6e5z, 6af5, 2r1u, 2or3, 4rkw, 3bwe, 4ogf, 4mnt, 1soa, 2r1v, 2r1t, 7c62, 5sy6 - hDJ-1 - human
3f71, 3ezg, 2rk6, 2rk4, 2rk3, 3b3a, 3b36, 3b38, 4oq4, 4s0z, 6af7, 3cyf, 3cy6, 3cza, 3cz9, 4rky, 4n12, 4n0m, 4mtc, 5sy9, 5sya - hDJ-1 (mutant)
6af9, 6afb, 6afa - hDJ-1 + isatin
6afl, 6afd, 6afc, 6aff, 6afe, 6afh, 6afg, 6afj, 6afi, 7pa2, 7pa3 - hDJ-1 + inhibitor
4e08 - DJ-1β - Drosofila melanogaster
4ogg, 4ofw, 3uk7 - DJ-1D - Arabidopsis thaliana
