Pyruvate dehydrogenase

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E. coli pyruvate dehydrogenase dimer complex with thiamine diphosphate and Mg+2 ion (green) (PDB code 1l8a).

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  1. Protein: Pyruvate dehydrogenase E1-beta, PdhB, C-terminal domain from Bacillus stearothermophilus. (2009). Retrieved from
  2. Ciszak EM, Korotchkina LG, Dominiak PM, Sidhu S, Patel MS (June 2003). "Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase". J. Biol. Chem. 278 (23): 21240–6
  3. 3.0 3.1 Arjunan P, Nemeria N, Brunskill A, Chandrasekhar K, Sax M, Yan Y, Jordan F, Guest JR, Furey W. Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution. Biochemistry. 2002 Apr 23;41(16):5213-21. PMID:11955070
  4. Jmol: an open-source Java viewer for chemical structures in 3D.
  5. 5.0 5.1 5.2 Voet, D., Voet, J.G., and Pratt, C.W. (2008). Fundamentals of biochemistry. Hoboken, NJ: John Wiley and Sons, Inc.
  6. Korotchkina LG, Patel MS. Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites. J Biol Chem. 2001 Feb 23;276(8):5731-8. Epub 2000 Nov 22. PMID:11092882 doi:10.1074/jbc.M007558200
  7. Roche TE, Hiromasa Y. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell Mol Life Sci. 2007 Apr;64(7-8):830-49. PMID:17310282 doi:10.1007/s00018-007-6380-z
  8. Bisswanger, H. Substrate specificity of the pyruvate dehydrogenase complex from escherichia coli. J Biol Chem. 1981. Jan 25;256(2):815-822.
  9. Leung PS, Rossaro L, Davis PA, et al. (2007). "Antimitochondrial antibodies in acute liver failure: Implications for primary biliary cirrhosis". Hepatology 46 (5): 1436
  10. Frye, Richard E., and Paul J. Benke. "Pyruvate Dehydrogenase Complex Deficiency." EMedicine. 11 Dec. 2007. WebMD. 14 Dec. 2008

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