Ribosomal protein L23

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Function

Ribosomal protein L23 (RPL23) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL23 binds to 23S or 26S RRNA[1].

Relevance

RPL23 promotes multi drug resistance in gastric cancer cells[2].

Ribosomal protein L23 NMR structure (PDB code 1n88)

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3D Structures of Ribosomal protein L23

Updated on 29-December-2019

Ribosomal protein L23
L23 in part of 50S ribosome
Ribosomal protein L23 in part of 80S ribosome
Ribosomal protein L23 in part of 60S ribosome

References

  1. ↑ Dai MS, Zeng SX, Jin Y, Sun XX, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004 Sep;24(17):7654-68. PMID:15314173 doi:http://dx.doi.org/10.1128/MCB.24.17.7654-7668.2004
  2. ↑ Shi Y, Zhai H, Wang X, Han Z, Liu C, Lan M, Du J, Guo C, Zhang Y, Wu K, Fan D. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. Exp Cell Res. 2004 Jun 10;296(2):337-46. PMID:15149863 doi:http://dx.doi.org/10.1016/j.yexcr.2004.02.009

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