SARS-CoV-2 protein M

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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.
Model Confidence:

  Very high (pLDDT > 90)

  Confident (90 > pLDDT > 70)

  Low (70 > pLDDT > 50)

  Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.

To the right is an AlphaFold2 3D model of SARS CoV-2 Protein M (length=222 amino acids, UniProt ID: P0DTC5) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 4[1].

Function

Disease

Function

Protein M Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.[1][2] [3].

Disease

Relevance

Structural highlights

Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein M, rainbow color coded N-C (blue to red).
Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein M, rainbow color coded N-C (blue to red)[1].












See also

Coronavirus_Disease 2019 (COVID-19)
SARS-CoV-2_virus_proteins
COVID-19 AlphaFold2 Models


SARS-CoV-2 Protein M Rank 1 Model 4 colored by pLDDT score
Drag the structure with the mouse to rotate

References

  1. ↑ 1.0 1.1 1.2 MIT ColabFold
  2. ↑ Modeling of the SARS-COV-2 Genome
  3. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129

Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman, Jaime Prilusky

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