SARS-CoV-2 protein NSP15

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This is the structure of NendoU (PDB code 6vww).


  1. Ulferts R, Ziebuhr J. Nidovirus ribonucleases: Structures and functions in viral replication. RNA Biol. 2011 Mar-Apr;8(2):295-304. doi: 10.4161/rna.8.2.15196. Epub 2011 Mar 1. PMID:21422822 doi:
  2. 2.0 2.1 2.2 2.3 Kim Y, Jedrzejczak R, Maltseva NI, Wilamowski M, Endres M, Godzik A, Michalska K, Joachimiak A. Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2. Protein Sci. 2020 Apr 17. doi: 10.1002/pro.3873. PMID:32304108 doi:
  3. Deng X, Hackbart M, Mettelman RC, O'Brien A, Mielech AM, Yi G, Kao CC, Baker SC. Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4251-E4260. doi:, 10.1073/pnas.1618310114. Epub 2017 May 8. PMID:28484023 doi:
  4. Liu X, Fang P, Fang L, Hong Y, Zhu X, Wang D, Peng G, Xiao S. Porcine deltacoronavirus nsp15 antagonizes interferon-beta production independently of its endoribonuclease activity. Mol Immunol. 2019 Oct;114:100-107. doi: 10.1016/j.molimm.2019.07.003. Epub 2019, Jul 24. PMID:31351410 doi:

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