| Theoretical Model:
The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. |
Model Confidence:
Confident (90 > pLDDT > 70)
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.
To the right is an AlphaFold2 3D model of SARS CoV-2 Protein NSP4 (length = 500 amino acids, i.e. YP_009725300.1, color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 1[1].
Morph of the top 5 ranked
AlphaFold2 models of
SARS-CoV-2 Protein NSP4,
rainbow color coded N-C (blue to red)
[1].
Function
Non-structural protein 4 (nsp4)
Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication[2][3].
It helps build fluid-filled bubbles within infected cells. Inside these bubbles, parts for new copies of the virus are constructed[4].
Structural Highlights
See also
Coronavirus_Disease 2019 (COVID-19)
SARS-CoV-2_virus_proteins
COVID-19 AlphaFold2 Models
