SARS Coronavirus Main Proteinase

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Human SARS coronavirus proteinase dimer complex with benzoic acid, dimethylamino benzoic acid and DMSO, 2vj1

3D structures of virus proteinase

See Virus protease 3D structures

References

  1. Takahashi D, Hiromasa Y, Kim Y, Anbanandam A, Yao X, Chang KO, Prakash O. Structural and dynamics characterization of norovirus protease. Protein Sci. 2013 Jan 15. doi: 10.1002/pro.2215. PMID:23319456 doi:http://dx.doi.org/10.1002/pro.2215
  2. Murray, Patrick R., Ken S. Rosenthal, and Michael A. Pfaller. "Coronaviruses and Noroviruses." Medical Microbiology. 6th ed. Philadelphia: Mosby/Elsevier, 2009. 565-68. Print.
  3. Ziebuhr, J., Herold,J., and Siddell, S.G. (1995). Characterization of a human coronavirus (strain 229E) 3C-like proteinase activity. J. Virol. 69, 4331-4338.
  4. Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003;348:1953-1966
  5. "Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003". WHO. Retrieved 2008-10-31.
  6. Li W, Shi Z, Yu M, et al. (2005). "Bats are natural reservoirs of SARS-like coronaviruses". Science (journal) 310 (5748): 676–9. doi:10.1126/science.1118391. PMID 16195424.
  7. Ziebuhr, J., Snijder, E.J., and Gorbaleya, A.E. (2000). Virus-encoded proteinases and proteolytic processing in Nidovirales. J. Gen. Virol. 81, 853-879.
  8. Anad, K., Ziebhr, J., Wadhani, P., Mesters, J.R., and Hilgenfeld, R. (2003). Coronavirus main protease (3CLPro) structure: basis for design of anti-SARS drugs. Science300, 1763-1767.
  9. Anad, K., Ziebhr, J., Wadhani, P., Mesters, J.R., and Hilgenfeld, R. (2003). Coronavirus main protease (3CLPro) structure: basis for design of anti-SARS drugs. Science300, 1763-1767.
  10. Verschueren, Koen H.G., Ksenia Pumpor, Stefan Anemüller, Shuai Chen, Jeroen R. Mesters, and Rolf Hilgenfeld. "A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters." Chemistry & Biology 15.6 (2008): 597-606. Web. Oct. 2010.

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