Serum Paraoxonase

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PON1 - looking down 6-bladed propellers, Ca+2 (green) and phosphate (stick model) ions seen 1v04

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3D structures of paraoxonase

Updated on 03-November-2020

1v04 – dePON + Ca + phosphate – directed evolution
6g82, 6gmu, 6h0a – dePON + Ca
4hho, 4hhq – dePON + Ca + Br
3sre – dePON + Ca + Br + phosphate
4q1u – dePON (mutant) + Ca + Br + phosphate
3srg – dePON + Ca + Br + oxoquinoline
5l2p – SsPON – Sulfolobus solfataricus
2vc7, 3uf9 – SsPON + thiophenium derivative + Co + Fe
4kf1 – SsPON (mutant) + Co + Fe + thiophenium derivative
2vc5 – SsPON + Co + Fe
4ke4, 4kes, 4ket, 4keu, 4kev, 4kez, 5vri, 5vrk, 5vsa, 5w3u, 5w3w, 5w3z – SsPON (mutant) + Co + Fe


  1. Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nat Struct Mol Biol. 2004 May;11(5):412-9. Epub 2004 Apr 18. PMID:15098021 doi:10.1038/nsmb767
  2. Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS. Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nat Chem Biol. 2011 Feb;7(2):120-5. Epub 2011 Jan 9. PMID:21217689 doi:10.1038/nchembio.510
  3. Ben-David M, Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS. Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. J Mol Biol. 2013 Mar 25;425(6):1028-38. doi: 10.1016/j.jmb.2013.01.009. Epub 2013, Jan 11. PMID:23318950 doi:10.1016/j.jmb.2013.01.009
  4. Ben-David M, Elias M, Filippi JJ, Dunach E, Silman I, Sussman JL, Tawfik DS. Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1. J Mol Biol. 2012 Mar 1. PMID:22387469 doi:10.1016/j.jmb.2012.02.042
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