Signalosome

From Proteopedia

spinqualitylabelsall models Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code 4d10) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image COP9 (COnstitutive Photomorphogenesis 9) signalosome catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome[1].

3D Structures of COP9 signalosome

Updated on 20-November-2023

4lct – hCOP9 subunit 1 – human
6a73 – hCOP9 subunit 2 + IP6
4d0p – hCOP9 subunit 4
1ufm – hCOP9 subunit 4 PCI domain - NMR
4f7o – hCOP9 subunit 5
5jog, 5joh, 5m5q – hCOP9 subunit 5 + inhibitor
4qft – hCOP9 subunit 6
4e0q, 4r14 – hCOP9 subunit 6 MPN domain
4d10, 4d18, 4wsn – hCOP9 subunits 1,2,3,4,5,6,7A,8
6r7n, 6r7i, 6r7h – hCOP9 subunits 1,2,3,4,8 + elongin + RBX1 + CSN7B + cullin-2 – Cryo EM
6r7f – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 + Nedd8 – Cryo EM
8h3f – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 – Cryo EM
8h38, 8h3a – hCOP9 subunits 1,2,3,4,5,6,7B,8 + RBX1 + Kbtbd2 + cullin-3 + Nedd8 – Cryo EM
6r6h – hCOP9 subunits 1,2,3,4,5,6,7B,8 + elongin + RBX1 + PVHL + cullin-2 – Cryo EM
3chm – hCOP9 subunit 7 – Arabidopsis thaliana
7enf, 7ewm – COP9 subunit 12 + Thp3 + 26S proteasome subunit Sem1 – yeast

References

1. ↑ Huang X, Hetfeld BK, Seifert U, Kahne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005 Aug;272(15):3909-17. PMID:16045761 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04807.x