Syntaxin-binding protein

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Function

Syntaxin-binding proteins (STXBP) are involved in the regulation of synaptic vesicle docking and fusion. STXBP1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding Syntaxin-1 and as a fusion protein that binds SNARE complexes in a Syntaxin-1 N-peptide-dependent manner[1]. STXBP2 binds SNARE proteins.

Structural highlights

Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1 which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions[1].


Rat syntaxin-binding protein 1 (green) complex with syntaxin-1 N-terminal peptide (magenta) (PDB code 3puj)

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3D structures of syntaxin-binding protein

Updated on 11-December-2023

Syntaxin-binding protein 1 or Munc18-1
Syntaxin-binding protein 2 or Munc18-2
Syntaxin-binding protein 3 or Munc18-3
Syntaxin-binding protein 4

References

  1. ↑ 1.0 1.1 Hu SH, Christie MP, Saez NJ, Latham CF, Jarrott R, Lua LH, Collins BM, Martin JL. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A. 2010 Dec 30. PMID:21193638 doi:10.1073/pnas.0914906108

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Michal Harel, Alexander Berchansky

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