TATA-Binding Protein
From Proteopedia
FunctionTATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation[1]. Called the TATA box to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also Additional informationSee: Transcription for additional Proteopedia resources RelevanceTBP is associated with aggregated proteins in several of the polyglutamine disorders like cerebellar ataxia[2]. Structural highlightsinteract with the phosphate groups The interactions of TBP with the DNA TATA box occurs with the minor groove of the DNA. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic[3]. 3D Structures of TATA-binding proteinTATA-binding protein 3D structures
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References
- ↑ Caporaso N. Genetic susceptibility in the occupational setting: introduction to the workshop. Med Lav. 1995 May-Jun;86(3):199-206. PMID:7565278
- ↑ van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. TATA-binding protein in neurodegenerative disease. Neuroscience. 2005;133(4):863-72. PMID:15916858 doi:http://dx.doi.org/10.1016/j.neuroscience.2005.03.024
- ↑ Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE. How proteins recognize the TATA box. J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291 doi:10.1006/jmbi.1996.0456
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