TATA-Binding Protein

From Proteopedia

Jump to: navigation, search

Contents

Function

TATA-Binding Protein (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex. The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation[1]. Called the TATA box to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif. See also

Additional information

See: Transcription for additional Proteopedia resources

Relevance

TBP is associated with aggregated proteins in several of the polyglutamine disorders like cerebellar ataxia[2].

Structural highlights

interact with the phosphate groups

phenylalanine amino acids

asparagine amino acids

two symmetrical halves.

The interactions of TBP with the DNA TATA box occurs with the minor groove of the DNA. The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic[3].

3D Structures of TATA-binding protein

TATA-binding protein 3D structures


Human TATA-binding protein complex with DNA TATA box (PDB code 1tgh)

Drag the structure with the mouse to rotate

References

  1. Caporaso N. Genetic susceptibility in the occupational setting: introduction to the workshop. Med Lav. 1995 May-Jun;86(3):199-206. PMID:7565278
  2. van Roon-Mom WM, Reid SJ, Faull RL, Snell RG. TATA-binding protein in neurodegenerative disease. Neuroscience. 2005;133(4):863-72. PMID:15916858 doi:http://dx.doi.org/10.1016/j.neuroscience.2005.03.024
  3. Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE. How proteins recognize the TATA box. J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291 doi:10.1006/jmbi.1996.0456

Proteopedia Page Contributors and Editors (what is this?)

Ala Jelani, Michal Harel, Eran Hodis, Alexander Berchansky, David Canner

Personal tools