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WWP2 Ubiquitin Ligase Chimeric Structure (PDB entry 5TJ7). The 2,3-linker (red) connects the WW2 domain (yellow) to the WW3 domain. The hinge (magenta) connects the C-terminal lobe (green) and N-terminal lobe (silver) of the HECT domain.

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  1. Ingham RJ, Gish G, Pawson T. The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene. 2004 Mar 15;23(11):1972-84. doi: 10.1038/sj.onc.1207436. PMID:15021885 doi:http://dx.doi.org/10.1038/sj.onc.1207436
  2. Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell. 2017 May 4;66(3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020. PMID:28475870 doi:http://dx.doi.org/10.1016/j.molcel.2017.03.020
  3. Chen W, Jiang X, Luo Z. WWP2: a multifunctional ubiquitin ligase gene. Pathol Oncol Res. 2014 Oct;20(4):799-803. doi: 10.1007/s12253-014-9838-y. Epub, 2014 Sep 13. PMID:25216927 doi:http://dx.doi.org/10.1007/s12253-014-9838-y

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