Sandbox UC 11

From Proteopedia

Directed evolution and Colicin7/Immunity-proteins complexes^[2]

1. ↑ ^{1.0 1.1} Fotinou C, Emsley P, Black I, Ando H, Ishida H, Kiso M, Sinha KA, Fairweather NF, Isaacs NW. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. J Biol Chem. 2001 Aug 24;276(34):32274-81. Epub 2001 Jun 19. PMID:11418600 doi:10.1074/jbc.M103285200
2. ↑ Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS. Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. Epub 2009 Sep 13. PMID:19749752 doi:10.1038/nsmb.1670

Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1mnm, resolution 2.25Å ()
Structural annotation: Resources: CATH : 1Mnmc00, 1Mnmd00 InterPro : Ipr002100, Ipr001356, Ipr012287, Ipr009057 Pfam : PF00319, PF00046 SCOP : d1mnma_, d1mnmb_, d1mnmc_, d1mnmd_ UniProt : P11746, Q6B2C0
Functional annotation: Cellular component: nuclear chromatin nucleus Biological process: regulation of transcription from RNA polymerase II promoter cell cycle transcription DNA replication initiation regulation of transcription, DNA-dependent donor selection regulation of transcription Molecular function: DNA bending activity sequence-specific DNA binding transcription factor activity DNA replication origin binding DNA binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Additional Literature

• Kleanthous C, Kuhlmann UC, Pommer AJ, Ferguson N, Radford SE, Moore GR, James R, Hemmings AM. Structural and mechanistic basis of immunity toward endonuclease colicins. Nat Struct Biol. 1999 Mar;6(3):243-52. PMID:10074943 doi:http://dx.doi.org/10.1038/6683
• Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS. Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. Epub 2009 Sep 13. PMID:19749752 doi:10.1038/nsmb.1670

External Resources

• Yahoo news coverage of luciferase studies funded research for military applications
• Luciferase at Wikipedia
• Luciferase: June 2006 Molecule of the Month as part of the series of tutorials that are at the RCSB Protein Data Bank and written by
• Lipase, the main article in Proteopedia.
• Molecular Playground/Pancreatic Lipase
• Lipase in Wikipedia