Monooxygenase 3D structures: Difference between revisions

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**[[4fni]] – SaIsdI (mutant) + heme-Fe + CN<br />
**[[4fni]] – SaIsdI (mutant) + heme-Fe + CN<br />
**[[4nl5]] – MtMO + heme + CN – ''Mycobacterium tuberculosis''<br />
**[[4nl5]] – MtMO + heme + CN – ''Mycobacterium tuberculosis''<br />
**[[6ds7]], [[6ds8]] - MtHO (mutant) + heme <br />
**[[6ds7]] - MtHO (mutant) + heme <br />
**[[6ds8]] – MtMO (mutant) + heme-Mn <br />
**[[4oz5]] – MO + heme – ''Bacillus subtilis''<br />
**[[4oz5]] – MO + heme – ''Bacillus subtilis''<br />
**[[8avh]] – BcMO – ''Bacillus cereus''<br />
**[[8avi]] - BcHO + heme <br />


*'''Kynurenine 3-monooxygenase (KMO)'''
*'''Kynurenine 3-monooxygenase (KMO)'''


**[[5x68]] – hKMO + FAD - human<br />
**[[5x68]] – hKMO + FAD - human<br />
**[[6lkd]], [[6lke]] – rKMO + FAD + inhibitor - rat<br />
**[[4j2w]], [[4j31]], [[4j33]], [[4j34]] – yKMO + FAD – yeast<br />
**[[4j2w]], [[4j31]], [[4j33]], [[4j34]] – yKMO + FAD – yeast<br />
**[[4j36]], [[5x6r]] – yKMO + FAD + inhibitor<br />
**[[4j36]], [[5x6r]] – yKMO + FAD + inhibitor<br />
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**[[5nak]] – PfKMO (mutant) + FAD + kynurenine <br />
**[[5nak]] – PfKMO (mutant) + FAD + kynurenine <br />
**[[5y66]] – PfKMO + FAD + kynurenine + inhibitor<br />
**[[5y66]] – PfKMO + FAD + kynurenine + inhibitor<br />
**[[6fph]], [[6fp1]], [[6fp0]], [[6foz]], [[6foy]] – PfKMO + FAD + inhibitor<br />
**[[6fph]], [[6fp1]], [[6fp0]], [[6foz]], [[6foy]], [[9az8]], [[9b07]], [[9b2y]] – PfKMO + FAD + inhibitor<br />
**[[5nah]], [[5nag]], [[5nae]], [[5nab]], [[5n7t]], [[5mzk]], [[5mzi]], [[5mzc]], [[5fn0]] – PfKMO (mutant) + FAD + inhibitor<br />
**[[5nah]], [[5nag]], [[5nae]], [[5nab]], [[5n7t]], [[5mzk]], [[5mzi]], [[5mzc]], [[5fn0]] – PfKMO (mutant) + FAD + inhibitor<br />


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**[[2gv8]] – fyMO + FAD + NADP – fission yeast<br />
**[[2gv8]] – fyMO + FAD + NADP – fission yeast<br />
**[[2gvc]] – fyMO + FAD + NADP + methimazole<br />
**[[2gvc]] – fyMO + FAD + NADP + methimazole<br />
**[[4a9w]] – SmMO + FAD – ''Stenotrophomonas maltophilia''<br />
**[[4a9w]], [[8aq8]] – SmMO + FAD – ''Stenotrophomonas maltophilia''<br />
**[[4c5o]] – SmMO (mutant) + FAD <br />
**[[4c5o]] – SmMO (mutant) + FAD <br />
**[[5wan]] – EcMO + FMN + uracil – Escherichia coli<br />
**[[5wan]] – EcMO + FMN + uracil – Escherichia coli<br />
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**[[6u0p]] – StMO + FAD – ''Streptomyces''<br />
**[[6u0p]] – StMO + FAD – ''Streptomyces''<br />
**[[6u0s]] – StMO + FAD + pyridine derivative<br />
**[[6u0s]] – StMO + FAD + pyridine derivative<br />
**[[7d4k]], [[7d4m]], [[7d4n]] – MO + FAD + NADP – ''Candidatus pelagibacter''<br />
**[[6sem]] – anMO + FAD - ancestral<br />
**[[6se3]], [[6sek]], [[6sf0]], [[7al4]] – anMO + FAD + NADP <br />
**[[6hns]] – MO + FAD + NADP – ''Nitricola lacisaponensis''<br />
**[[8z17]] – SaMO + FAD + NADP <br />
**[[8b2d]] – MO + FAD + NADP – ''Methylophaga aminisulfidivorans''<br />


*'''2,4,6-trichlorophenol 4-monooxygenase'''
*'''2,4,6-trichlorophenol 4-monooxygenase'''
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**[[3k88]] – BcMO + FAD + NAD  <br />
**[[3k88]] – BcMO + FAD + NAD  <br />
**[[6jhm]] – MO – ''Ralstonia pickettii''<br />
**[[6jhm]] – MO – ''Ralstonia pickettii''<br />
**[[7e8p]], [[7e8q]] – RpMO + FAD derivative + nitrophenol <br />


*'''Phenylacetone monooxygenase'''
*'''Phenylacetone monooxygenase'''
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**[[4ovi]], [[4c74]] – TfMO + FAD + APADP – ''Thermobifida fusca''<br />
**[[4ovi]], [[4c74]] – TfMO + FAD + APADP – ''Thermobifida fusca''<br />
**[[1w4x]] – TfMO + FAD<br />
**[[1w4x]] – TfMO + FAD<br />
**[[2ylt]], [[2yls]], [[2ylr]] – TfMO + FAD + NADP <br />
**[[2ylr]], [[2yls]], [[2ylt]], [[8xg8]] – TfMO + FAD + NADP <br />
**[[2ylz]] – TfMO (mutant) + FAD  <br />
**[[2ylz]] – TfMO (mutant) + FAD  <br />
**[[4c77]] – TfMO (mutant) + FAD + APADP <br />
**[[4c77]] – TfMO (mutant) + FAD + APADP <br />
**[[4d04]] – TfMO (mutant) + FAD + NAP <br />
**[[4d04]] – TfMO (mutant) + FAD + NAP <br />
**[[4d03]], [[2ym2]], [[2ylx]], [[2ylw]] – TfMO (mutant) + FAD + NADP <br />
**[[2ylw]], [[2ylx]], [[2ym2]], [[4d03]], [[8xg7]], [[8xg9]] – TfMO (mutant) + FAD + NADP <br />
**[[2ym1]] – TfMO (mutant) + FAD + NADP + O2<br />
**[[2ym1]] – TfMO (mutant) + FAD + NADP + O2<br />


*'''6-hydroxynicotinate 3-monooxygenase'''
*'''6-hydroxynicotinate 3-monooxygenase or NicC'''


**[[5eow]] – PpMO + FAD – ''Pseudomonas putida''<br />
**[[5eow]] – PpMO + FAD – ''Pseudomonas putida''<br />
**[[8uiv]] – PpMO (mutant) + FAD <br />
**[[8uiq]] – PpMO + FAD + pyridinethiol<br />
**[[8twf]] – MO + FAD – ''Legionella massiliensis''<br />


*'''Styrene monooxygenase'''
*'''Styrene monooxygenase'''
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**[[3ihm]] – PpMO  <br />
**[[3ihm]] – PpMO  <br />
**[[4f07]] – PpMO (mutant) + FAD <br />
**[[4f07]] – PpMO (mutant) + FAD <br />
**[[9j0h]] – PpMO (mutant) – ''Streptomyces vilmorinianum''<br />


*'''Tryptophan 2-monooxygenase'''
*'''Tryptophan 2-monooxygenase'''
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**[[4iv9]] – MO + FAD – ''Pseudomonas savastanoi''<br />
**[[4iv9]] – MO + FAD – ''Pseudomonas savastanoi''<br />


*'''Tryptophan 5-monooxygenase'''
*'''Tryptophan 5-monooxygenase or tryptophan 5-hydroxylase'''


**[[1mlw]] – hMO + Fe + dihydrobiopterin <br />
**[[1mlw]] – hMO + Fe + dihydrobiopterin <br />
**[[7zic]], [[7zig]], [[7zij]], [[8cjk]], [[8cjl]], [[8cjn]] – hMO1 + Fe + inhibitor<br />
**[[7wiy]], [[9hb7]] – hMO2 + Fe + inhibitor<br />
**[[9he3]] – hMO1 + Fe + drug<br />


*'''Tyrosine 3-monooxygenase'''
*'''Tyrosine 3-monooxygenase'''


**[[2xsn]] – hMO + Zn<br />
**[[2xsn]] – hMO + Zn<br />
**[[2toh]] – rMO + Fe + dihydrobiopterin + tyrosine - rat<br />
**[[2toh]] – rMO + Fe + dihydrobiopterin + tyrosine y<br />
**[[2mda]] – rMO regulatory domain <br />
**[[2mda]] – rMO regulatory domain <br />


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**[[6bka]] – MO + FMN – ''Cyberlyndnera mrakii''<br />
**[[6bka]] – MO + FMN – ''Cyberlyndnera mrakii''<br />


*'''2-hydroxbiphenyl 3-monooxygenase'''
*'''2-hydroxybiphenyl 3-monooxygenase'''


**[[4z2r]] – PnMO + FAD – ''Pseudomonas nitroreducens''<br />
**[[4z2r]], [[6em0]] – PnMO + FAD – ''Pseudomonas nitroreducens''<br />
**[[4cy6]] – PnMO (mutant)  <br />
**[[4cy6]] – PnMO (mutant)  <br />
**[[4z2u]], [[4z2t]], [[4cy8]], [[6em0]] – PnMO (mutant) + FAD <br />
**[[4z2u]], [[4z2t]], [[4cy8]], [[6em0]] – PnMO (mutant) + FAD <br />
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**[[4ira]] – BmMO + FAD – ''Brucella melitensis''<br />
**[[4ira]] – BmMO + FAD – ''Brucella melitensis''<br />
**[[3cb0]] – BmMO + FMN<br />
**[[3cb0]] – BmMO + FMN<br />
**[[6eb0]] – EcMO oxygenase subunit<br />
**[[6eb0]], [[6qyh]] – EcMO oxygenase subunit<br />
**[[6b1b]] – EcMO oxygenase subunit (mutant)<br />
**[[6b1b]] – EcMO oxygenase subunit (mutant)<br />
**[[9bke]] – EcMO oxygenase subunit (mutant) + AMP<br />
**[[6qyi]] – EcMO oxygenase subunit + FAD<br />
**[[9lft]] – MO – ''Geobacillus mahadii''<br />


*'''Ornithine N(5)-monooxygenase'''
*'''Ornithine N(5)-monooxygenase'''
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**[[4nzh]], [[4b69]] – AfMO + FAD + ornithine <br />
**[[4nzh]], [[4b69]] – AfMO + FAD + ornithine <br />
**[[6x0k]] – AfMO (mutant) + FAD + ornithine <br />
**[[6x0k]] – AfMO (mutant) + FAD + ornithine <br />
**[[4b65]] – AfMO + FAD + NADP  <br />
**[[6x0h]], [[7jvk]] – AfMO (mutant) + FAD <br />
**[[4b65]], [[6x0i]] – AfMO + FAD + NADP  <br />
**[[7jvl]] – AfMO (mutant) + FAD + NADP  <br />
**[[4b68]], [[4b66]] – AfMO + FAD + NAP + arginine <br />
**[[4b68]], [[4b66]] – AfMO + FAD + NAP + arginine <br />
**[[4b67]], [[4b63]] – AfMO + FAD + NADP + ornithine <br />
**[[4b67]], [[4b63]] – AfMO + FAD + NADP + ornithine <br />
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*'''Cyclohexanone monooxygenase'''
*'''Cyclohexanone monooxygenase'''


**[[5m10]] – TmMO + FAD + NAP + nicotinamide – ''Thermocripsum municipale''<br />
**[[7v8r]] – TmMO + FAD + NAP – ''Thermocripsum municipale''<br />
**[[7v8o]], [[7v8s]] – TmMO (mutant) + FAD + NAP <br />
**[[5m10]] – TmMO + FAD + NAP + nicotinamide <br />
**[[5m0z]] – TmMO + FAD + NADP derivative <br />
**[[5m0z]] – TmMO + FAD + NADP derivative <br />
**[[6gqi]] – TmMO + FAD + NADP + hexanic acid <br />
**[[6gqi]] – TmMO + FAD + NADP + hexanic acid <br />
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**[[4rg4]], [[4rg3]], [[3gwf]], [[3gwd]] – RhMO + FAD + NAP + caprolactone <br />
**[[4rg4]], [[4rg3]], [[3gwf]], [[3gwd]] – RhMO + FAD + NAP + caprolactone <br />
**[[3ucl]] – RhMO + FAD + NADP + cyclohexanone <br />
**[[3ucl]] – RhMO + FAD + NADP + cyclohexanone <br />
**[[7v4x]] – AcMO + FAD + NADP – Acinetobacter calcoaceticus<br />
**[[8yq3]], [[8yqm]], [[8yrb]], [[8ytt]], [[8yu0]], [[8yu2]], [[8yu4]], [[9orn]] – AcMO (mutant) + FAD + NADH <br />


*'''Lysine 6-monooxygenase'''
*'''Lysine 6-monooxygenase'''
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**[[6ju1]] – PaMO (mutant) + dihydroxybenzoate<br />
**[[6ju1]] – PaMO (mutant) + dihydroxybenzoate<br />
**[[8y2s]] – PaMO + FAD + benzoate derivative<br />
**[[8jqq]] – MO + FAD – ''Xylophilus ampelinus''<br />
**[[8weq]] – MO + FAD – ''Arthrobacter''<br />


*'''FAD monooxygenase'''
*'''FAD monooxygenase'''
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**[[6pvh]]. [[6pvi]] – PfMO + FAD + paraherquamide <br />
**[[6pvh]]. [[6pvi]] – PfMO + FAD + paraherquamide <br />


*'''Lytic polysaccharide monooxygenase'''
*'''Lytic polysaccharide monooxygenase''' or '''LPMO'''


**[[5tki]], [[5foh]], [[4qi8]] – NcMO-2 + Cu – ''Neurospora crassa''''Italic text''<br />
**[[5msz]] – MO + Cu – firebrat<br />
**[[6if7]] – MO – fern<br />
**[[7ntl]] – MO + Cu – fungus<br />
**[[4mai]] – moMO + Cu – mold<br />
**[[4mah]] – moMO + Zn<br />
**[[5tki]], [[5foh]], [[4qi8]], [[7t5c]], [[7t5e]] – NcMO-2 + Cu – ''Neurospora crassa''''Italic text''<br />
**[[5tkh]], [[5tkg]], [[5tkf]], [[4eir]] – NcMO-2 + Cu + O2 <br />
**[[5tkh]], [[5tkg]], [[5tkf]], [[4eir]] – NcMO-2 + Cu + O2 <br />
**[[4eis]] – NcMO-3 + Cu + peroxide <br />
**[[4eis]] – NcMO-3 + Cu + peroxide <br />
**[[5iju]] – MO + Cu – ''Bacillus amyloliquefaciens''<br />
**[[5iju]] – MO + Cu – ''Bacillus amyloliquefaciens''<br />
**[[5acj]], [[5aci]], [[5ach]], [[5acg]], [[5acf]] – MO + Cu – ''Lentinus similis''<br />
**[[5acj]], [[5aci]], [[5ach]], [[5acg]], [[5acf]] – MO + Cu – ''Lentinus similis''<br />
**[[4mai]] – moMO + Cu – mold<br />
**[[4mah]] – moMO + Zn<br />
**[[5no7]] – MO – ''Pycnoporus cinnabarinus''<br />
**[[5no7]] – MO – ''Pycnoporus cinnabarinus''<br />
**[[6ndq]] – MO – ''Kitsatospora papulosa''<br />
**[[6ndq]] – MO – ''Kitsatospora papulosa''<br />
**[[6ydc]], [[6ydd]], [[6yde]], [[6ydf]] – MO + Cu – ''Collariella virescens<''br />
**[[7a8v]] – MO + Cu – ''Talaromyces verruculosus<''br />
**[[5lsv]], [[5t7j]], [[5t7k]], [[5t7n]], [[6tbr]], [[6tc4]] – AoMO + Zn – ''Aspergillus oryxae''<br />
**[[6tbq]] – AoMO + Zn + Cu<br />
**[[6z5y]] – MO + Cu – ''Phytophthora infestans<''br />
**[[6t5z]] – MO + Cu – ''Photorhabdus laumondii''<br />
**[[5opf]] – MO + Cu – ''Micromonospora aurantiaca''<br />
**[[5fjq]], [[9i1u]] – MO + Cu – ''Cellvibrio japonicus''<br />
**[[5o2w]] – MO + Cu – ''Trichoderma reesei''<br />
**[[5l2v]] – MO + Cu – ''Listeria monocytogenes''<br />
**[[9hdg]] – AfMO + Cu + ascorbate<br />
**[[9fdl]] – TttMO + Cu – ''Thermothelomyces thermophilus''<br />
**[[9bjq]], [[9bjt]] – TttMO + Cu + O2 <br />
**[[9bjr]] – TttMO (mutant) + Cu + O2<br />
**[[9exj]] – AfMO + Cu <br />
**[[7sqx]] – PaMO <br />
**[[7pxl]], [[7pxr]], [[7pxs]], [[7pxt]], [[7pxv]], [[7pye]], [[7pyo]], [[7pyq]] – PsMO + Cu – ''Panus similis''<br />
**[[7pyd]], [[7pyf]], [[7pyg]], [[7pyi]], [[7pyp]], [[7pyz]] – PsMO + Cu + polysaccharide<br />
**[[8rry]] – MO + Cu – ''Serratia marcescens''<br />
**[[7pz8]] – MO – ''Thermoascus aurantiacus''<br />


*'''Peptidyl-glycine alpha-amidating monooxygenase'''
*'''Peptidyl-glycine alpha-amidating monooxygenase'''
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**[[6ao6]], [[5wja]], [[6nck]] – rMO (mutant) + Cu + Ni<br />
**[[6ao6]], [[5wja]], [[6nck]] – rMO (mutant) + Cu + Ni<br />
**[[1sdw]] – rMO + Cu + Ni + O2 + threonine derivative<br />
**[[1sdw]] – rMO + Cu + Ni + O2 + threonine derivative<br />
**[[1yjk]], [[1yip]], [[1phm]] – rMO + Cu<br />
**[[1yjk]], [[1yip]], [[1phm]], [[8dsj]], [[8dsl]] – rMO + Cu<br />
**[[1yi9]], [[6ay0]], [[6an3]], [[6amp]], [[6alv]], [[6ala]] – rMO (mutant) + Cu<br />
**[[1yi9]], [[6ay0]], [[6an3]], [[6amp]], [[6alv]], [[6ala]], [[8dsn]] – rMO (mutant) + Cu<br />
**[[3fw0]] – rMO + Hg<br />
**[[3fw0]] – rMO + Hg<br />
**[[3fvz]] – rMO + Zn + Fe<br />
**[[3fvz]] – rMO + Zn + Fe<br />
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**[[4dn9]] – MO – ''Chloroflexus aurantiacus''<br />
**[[4dn9]] – MO – ''Chloroflexus aurantiacus''<br />
**[[2ril]] – MO – ''Shewanella loihica''<br />
**[[2ril]] – MO – ''Shewanella loihica''<br />
**[[8eif]] – PaMO <br />
**[[8ecp]] – PaMO (mutant)<br />
**[[9lmm]] – ScMO <br />


*'''Monooxygenase'''
*'''Monooxygenase'''
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**[[6dvi]] – MsLMO + FMN – ''Mycobacterium smegmatis''<br />
**[[6dvi]] – MsLMO + FMN – ''Mycobacterium smegmatis''<br />
**[[6dvh]] – MsLMO (mutant) + FMN <br />
**[[6dvh]] – MsLMO (mutant) + FMN <br />
**[[4rje]] – AvLMO – ''Aerococcus viridans'' <br />
**[[2du2]], [[2e77]], [[2zfa]] – AvLMO + FMN <br />
**[[2nli]] – AvLMO + FMN + lactate<br />


*'''Squalene monooxygenase or squalene epoxidase'''
*'''Dimethyl-sulfide monooxygenase'''  


**[[6c6r]], [[6c6p]], [[6c6n]] – hSMO + FAD + inhibitor<br />
**[[6ak1]] – DMOA – ''Hyphomicrobium sulfonivorans''<br />


*'''Dimethyl-sulfide monooxygenase'''  
*'''TetX monooxygenase''' or Flavin-dependent monooxygenase
 
**[[2xdo]], [[2xyo]] – BtTetX2 – ''Bacterioides thetaiotaomicron''<br />
**[[2y6q]], [[2y6r]] – BtTetX2 + tetracycline derivative <br />
**[[7epv]] – EcTetX4 <br />
**[[7epw]] – EcTetX4 + tetracycline derivative <br />
**[[9hjw]] – EcTetX4 + drug<br />
**[[9hjv]], [[9hke]] – EcTetX4 + inhibitor<br />
**[[8er1]] – CoTetX6 – ''Chryseobacterium oncorhynchi'' <br />
**[[8er0]] – ECoetX6 + tetracycline derivative <br />
**[[8z12]], [[8z13]], [[8z14]], [[8z15]], [[8z16]] – MO + FAD + NADP – ''Streptomyces ardesiacus'' <br />
**[[8uiu]], [[8urc]] – NnMO + FAD – ''Neobacillus niacini''<br />
**[[8urd]] – NnMO + FAD + pyridine derivative – Cryo EM<br />
**[[9h8m]], [[9h8z]] – MO + FAD – ''Penicillium rubens''<br />
**[[7yj0]] – MO + FAD – ''Boreostereum vibrans''<br />
**[[8up4]] – MO + FAD – ''Streptomyces lasalocidi''<br />
**[[8t3p]] – MO + FAD – ''Streptomyces virginiae''<br />
**[[7vwp]] – MO + FAD – ''Micromonospora rosaria''<br />
 
*'''Particulate membrane monooxygenase (pMMO)'''
 
**[[7ev9]], [[7s4h]], [[7s4i]], [[7s4j]], [[7s4k]], [[7t4o]], [[7t4p]], [[8oyi]], [[8sqw]], [[8sr1]], [[8sr2]], [[8sr4]], [[8sr5]] – McpMMO alpha+beta subunits + ammonia monooxygenase/methane monooxygenase + Cu – ''Methylococcus capsulatus'' – Cryo EM<br />
**[[1yew]], [[3rgb]] – McpMMO alpha+beta+gamma subunits + Cu + Zn<br />
**[[7yzy]] – McpMMO alpha+beta+gamma subunits – Cryo EM<br />
**[[9cl1]], [[9cl2]], [[9cl3]], [[9cl4]] – McpMMO alpha+beta+gamma subunits + Cu – Cryo EM<br />
**[[6cxh]], [[7s4l]] – pMMO alpha+beta+gamma subunits + Cu – ''Methylotuvimicobium alcaliphilum'' – Cryo EM<br />
**[[3rfr]] – McypMMO alpha+beta+gamma subunits + peptide + Cu – ''Methylocystis'' <br />
**[[9cl5]] – McypMMO gamma subunit + ammonia monooxygenase/methane monooxygenase A+B subunits + Cu – Cryo EM<br />


**[[6ak1]] – DMOA – ''Hyphomicrobium sulfonivorans''<br />


'''Salicylate 1-monooxygenase''' or salicylate hydroxylase See [[Hydroxylase]]
'''Salicylate 1-monooxygenase''' or salicylate hydroxylase See [[Hydroxylase]]
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'''Luciferin 4-monooxygenase and Alkanal monooxygenase''' See [[Luciferase]]
'''Luciferin 4-monooxygenase and Alkanal monooxygenase''' See [[Luciferase]]


'''Phenylalanine 4-monooxygenase''' or phenylalanine-4-hydroxylase See [[Hydroxylase]]}}
'''Phenylalanine 4-monooxygenase''' or phenylalanine-4-hydroxylase See [[Hydroxylase]]
 
'''Squalene monooxygenase''' or squalene epoxidase See [[Epoxidase]]
 
}}


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 11:11, 24 March 2026

3D structures of monooxygenase

Updated on 24-March-2026

Salicylate 1-monooxygenase or salicylate hydroxylase See Hydroxylase Methane monooxygenase See Methane monooxygenase Camphor 5-monooxygenase See Cytochrome P450 Luciferin 4-monooxygenase and Alkanal monooxygenase See Luciferase Phenylalanine 4-monooxygenase or phenylalanine-4-hydroxylase See Hydroxylase Squalene monooxygenase or squalene epoxidase See Epoxidase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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