Beta-2 microglobulin

spinqualitylabelsall models Humanβ-2 microglobulin (green) complex with MHC I (magenta) and HCMV PP65 nonapeptide (cyan), 3mrb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Beta-2 microglobulin (B2M) is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. For more details, see: Human beta two microglobulin. Diagram of MHC I Complex Disease Elevated B2M levels are found in patients of liver chirossis. Relevance B2M is used as a marker for certain types of blood cell cancer. It can indicate the spread and severity of myeloma. Structural Highlights Human β-2 microglobulin with MHC class I HLA-A2 and HCMV PP65 nonapeptide (3mrb).

3D Structures of β-2 microglobulin

Updated on 28-December-2017

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• B2M
  • Human beta two microglobulin, 3mrb, 3ib4, 3ekc, 3dhj, 3dhm, 3ciq, 2z9t, 2d4d, 2f8o, 1py4, **3ov6, 3tlr, 3tm6, 4fxl, 5csg, 5csb, 5cs7, 5ckg, 5cka, 5cfh, 4rmw, 4rmv, 4rmu, 4rmt, 4rms, 4rmr, 4rmq, 4rah, 4ra3, 4r9h - hβ-2-microglobulin (mutant) – human
    
  • 3qda - hβ-2-microglobulin residues 21-119 (mutant)
    
  • 2xks, 2xku, 1jnj - hβ-2-microglobulin – NMR
    
  • 2vb5 - hβ-2-microglobulin (mutant) – NMR
    
  • 2e8d - hβ-2-microglobulin residues 40-61 - NMR
    
  • 3low, 2yxf, 2d4f, 1lds - hβ-2-microglobulin
    
  • 3gbl - gcβ-2-microglobulin residues 1-97 - grass carp
    
  • 1bmg - bβ-2-microglobulin - bovine
    
  • 3loz - β-2-microglobulin – synthetic
    
  • 3o81 - cβ-2-microglobulin - chicken
    
  • 1cd1 - mβ-2-microglobulin - mouse
    
  • 4m9o - β-2-microglobulin – zebra fish
    
• B2M in binary complex with MHC
  • 1zs8, 1u58 - mβ-2-microglobulin + mMHC I – mouse
    
  • 1r3h - mβ-2-microglobulin + mMHC II extracellular domain
    
  • 2hla, 3hla, 1hla - hβ-2-microglobulin + hMHC I
    
  • 4gup - hβ-2-microglobulin + hMHC I (mutant)
    
  • 3p73, 3p77 - cβ-2-microglobulin + cMHC I
    
  • 1pdq - mβ-2-microglobulin + MCMV M144
    
• B2M in binary complex with CD1
  • 3s6c - hβ-2-microglobulin/hCD1E
    
  • 4ono - hβ-2-microglobulin/CD1C/CD1B
    
  • 4x6e, 5j1a - hβ-2-microglobulin + CD1A
    
  • 3t8x, 5l2j - hβ-2-microglobulin + hCD1B
    
  • 5c9j - hβ-2-microglobulin + CD1C
    
  • 3u0p - hβ-2-microglobulin + hCD1D (mutant)
    
  • 3ma7, 3ilp, 3ilq, 3g08, 3gml, 3gmm, 3gmn, 3gmo, 3gmp, 3gmq, 3gmr, 1zhn, 3t1f, 4mq7, 4mx7 - mβ-2-microglobulin + CD1D1
    
  • 2gaz, 2fik, 1z5l, 3au1 - mβ-2-microglobulin + CD1D1 extracellular domain
    
  • 2akr - mβ-2-microglobulin residues 21-119+ CD1D1 extracellular domain
    
  • 4f7c, 4f7e - bβ-2-microglobulin + CD1D
    
  • 2h26 - hβ-2-microglobulin + CD1B extracellular domain
    
  • 3l9r - bβ-2-microglobulin + CD1B3
    
  • 3jvg - cβ-2-microglobulin + CD1A1 ectodomain
    
• B2M in binary complex with other molecules
  • 1exu - hβ-2-microglobulin + Fc receptor
    
  • 3fru - rβ-2-microglobulin + Fc receptor - rat
    
  • 1c16 - mβ-2-microglobulin + protein T22
    
  • 1a6z - hβ-2-microglobulin + hemochromatosis protein
    
  • 2x89 - hβ-2-microglobulin + antibody
    
  • 4kdt - hβ-2-microglobulin + nanobody
    
  • 5bxf - hβ-2-microglobulin + Igg receptor
    
  • 3mzt - hβ-2-microglobulin + thioflavin
    
  • 1pqz - mβ-2-microglobulin + MCMV M144
    
  • 4iiq, 4l8s, 4l9l, 4lcc, 4lcw - bβ-2-microglobulin + Tc receptor
    
• B2M in ternary complex with MHC
  • 4d0b, 3bew, 4e0r, 4g42, 4g43 – cβ-2-microglobulin + cMHC I α + peptide
    
  • 2xfx - bβ-2-microglobulin + MHC I α + peptide
    
  • 3jts, 3jtt, 1zvs, 3rwc, 3rwd, 3rwe, 3rwf, 3rwg, 3rwh, 3rwi, 3rwj - β-2-microglobulin + MHC I α + peptide – Macaca mulatta
    
  • 3kpn, 3kpo – hβ-2-microglobulin + hMHC I B + peptide
    
  • 3bev, 1kpr, 1k5n, 3nfn, 3mr9, 3mrb, 3mrc, 3mrd, 3mre, 3mrf, 3mrg, 3mrh, 3mri, 3mrj, 3mrk, 3mrl, 3mrm, 3mrn, 3mro, 3mrp, 3mrq, 3mrr, 3ox8, 3oxr, 3oxs, 2xpg, 3pwj, 3pwl, 3pwn, 3pwp, 2x70, 3o3a, 3o3b, 3o3d, 3o3e, 3lv3, 3ln4, 3ln5, 3myj, 3i6l, 3lkn, 3lko, 3lkp, 3lkq, 3lkr, 3lks, 3hpj, 3i6g, 3i6k, 3mgo, 3mgt, 3l3d, 3l3g, 3l3h, 3l3i, 3l3j, 3l3k, 2x4n, 2x4o, 2x4p, 2x4q, 2x4r, 2x4s, 2x4t, 2x4u, 3lka, 3h7b, 3kpl, 3kpm, 3kpn, 3kpo, 3kpp, 3kpq, 3kpr, 3kps, 3giv, 3hcv, 3d18, 3dtx, 3czf, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3d25, 3bvn, 3dx6, 3dx7, 3dx8, 3dxa, 3bo8, 3bp4, 3bp7, 3bgm, 3bh8, 3bh9, 3bhb, 3b3i, 3b6s, 2rfx, 3bze, 3bzf, 3bw9, 3bwa, 3c9n, 2v2w, 2v2x, 2gt9, 2gtw, 2gtz, 2guo, 2nw3, 2fyy, 2fz3, 2hn7, 2cik, 2git, 2hjk, 2hjl, 2h6p, 2d31, 2c7u, 2bck, 2a83, 2axf, 2axg, 2bvo, 2bvp, 2bvq, 1s8d, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1s7q, 1zsd, 2bsr, 2bss, 2bst, 1zhk, 1zhl, 1tvb, 1tvh, 1xr8, 1xr9, 1w0v, 1w0w, 1xh3, 1uxs, 1uxw, 1s9w, 1s9x, 1s9y, 1q94, 1qvo, 1n2r, 1ogt, 1qew, 1jge, 1k5n, 1i7r, 1i7t, 1i7u, 1jf1, 1jht, 1i4f, 1e27, 1e28, 1i1y, 1i1f, 1qqd, 1mhe, 1b0g, 1a9b, 1a9e, 1a1m, 1a1n, 1a1o, 1tmc, 2clr, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hsb, 1hsa, 3kla, 3giv, 3d18, 3bxn, 1x7q, 1ydp, 1sys, 1of2, 1jgd, 1eey, 1eez, 1duy, 1duz, 1agb, 1agc, 1agd, 1age, 1agf, 3am8, 3qfd, 3rew, 3rl1, 3rl2, 3skm, 3sko, 3utq, 3uts, 3utt, 3vfm, 3vfn, 3vfo, 3vfp, 3vfr, 3vfs, 3vft, 3vfu, 3vfv, 3vfw, 3vh8, 2ypk, 3spv, 3tid, 3tie, 3to2, 3upr, 3v5d, 3v5h, 3v5k, 3vcl, 3vri, 3vrj, 4f7m, 4f7p, 4f7t, 4gks, 4i4w, 3w39, 4g8i, 4g9d, 4jqv, 4jqx, 4k7f, 1b0r, 3vxm, 3vxn, 3vxo, 3vxp, 3vxr, 3vxs, 3vxu, 3w0w, 4hwz, 4hx1, 4i48, 4nqv, 4nqx, 3wl9, 3wlb, 3ws3, 3ws6, 3x11, 3x12, 3x13, 3x14, 4hs3, 4lcy, 4lnr, 4mj5, 4mj6, 4nnx, 4nny, 4no2, 4no3, 4no5, 4nt6, 4o2c, 4o2e, 4o2f, 4pr5, 4pra, 4prb, 4prd, 4pre, 4prn, 4qrq, 4qrs, 4qrt, 4qru, 4u6x, 4u6y, 4uq2, 4uq3, 4wj5 - hβ-2-microglobulin + hMHC I α + peptide
    
  • 4l29, 4l3c, 5n1y, 5mer, 5meq, 5mep, 5meo, 5men, 5ind, 5inc, 5im7, 5iek, 5ieh, 5ib5, 5ib4, 5ib3, 5ib2, 5ib1, 5hhq, 5hhp, 5hho, 5hhn, 5hhm, 5hgh, 5hgd, 5hgb, 5hga, 5fdw, 5fa4, 5fa3, 5f9j, 5f7d, 5eu5, 5eu4, 5eu3, 5eot, 5eo1, 5eo0, 5enw, 5e00, 5deg, 5def, 5ddh, 5d9s, 5c0j, 5c0i, 5c0g, 5c0f, 5c0e, 5c0d, 4xxc, 4wu7, 4wu5. 4wdi, 4u1s, 4u1n, 4u1m, 4u1l, 4u1k, 4u1j, 4u1i, 4u1h - hβ-2-microglobulin + hMHC I α + NY-ES01
    
  • 1ktl, 3kww, 3h9h, 3ixa, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3ft2, 3ft3, 3ft4, 2av1, 2av7, 1cg9, 1m05, 1m6o, 1kpr, 1ktl, 3kyn, 3kyo, 1qr1 - β-2-microglobulin + hMHC I α (mutant) + peptide
    
  • 1syv, 1n2r - β-2-microglobulin + hMHC I + hMHC II peptide
    
  • 1kjv, 1kjm, 1ed3 – rβ-2-microglobulin + MHC I α + peptide
    
  • 3bev, 3bew, 2yf6, 5ad0, 2yez, 4d0c, 5acz - cβ-2-microglobulin + cMHC I α + peptide
    
  • 1kbg, 3l3h, 3ftg, 3e6f, 3ecb, 3ch1, 3cch, 3cc5, 3cpl, 2zsv, 2zsw, 2zok, 2zol, 3buy, 2ve6, 2e7l, 2fo4, 2cii, 2fwo, 2f74, 1zt1, 1zt7, 1vgk, 1yn6, 1yn7, 1zhb, 1wbx, 1wby, 1wbz, 1rjy, 1rjz, 1rk0, 1rk1, 1t0m, 1t0n, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1lk2, 1kpu, 1kpv, 1n3n, 1nan, 1n59, 1n5a, 1ffn, 1ffo, 1ffp, 1g7p, 1g7q, 1lek, 1leg, 1inq, 1juf, 1k8d, 1jpf, 1jpg, 1fg2, 1qlf, 1bz9, 1kbg, 1hoc, 2mha, 1vad, 1vac, 3fol, 3fom, 3fon, 1ce6, 1osz, 1bii, 1ld9, 2vaa, 2vab, 3p4m, 3p4n, 3p4o, 3p9l, 3p9m, 3pab, 3pwu, 3pwv, 3quk, 3qul, 3rol, 3roo, 3vj6, 1ldp, 3tbs, 3tbt, 3tbv, 3tbw, 4nsk, 3tby, 4huu, 4huv, 4huw, 4hux, 4hv8, 4pg2, 4pg9, 4pgb, 4pgc, 4pgd, 4pge, 4pv8, 4pv9, 5swq, 5j6h, 5e8p, 5e8o, 5e8n, 4z78, 4z77, 4z76 - mβ-2-microglobulin + mMHC I + peptide
    
  • 2qri, 3nwm - mβ-2-microglobulin/mMHC I/peptide
    
  • 2qrs, 2qrt - mβ-2-microglobulin/mMHC I (mutant )/peptide
    
  • 1mhc, 2clv, 2clz, 1fzj, 1fzk, 1fzm, 1fzo, 1ddh, 4iho, 4l8b, 4l8c, 4l8d – mβ-2-microglobulin + mMHC I (mutant) + peptide
    
  • 1ypz - mβ-2-microglobulin + mMHC II + T cell receptorbr />
  • 4l4t, 4l4v, 4nqc, 4nqd, 4nqe, 5pj5, 4pj7, 5pj8, 4pj9, 5pja, 4pjb, 5pjc, 4pjd, 5pje, 4pjf, 5pjg, 4pjh, 5pji, 4pjx, 4prh, 4pri, 4wo4, 5u72, 5u6q, 5u2v, 5u17, 5u16, 5d7l, 5d7j, 5d7i, 5d5m, 4pji, 4pjg, 4pje, 4pjc, 4pja, 4pj8, 4pj5 - hβ-2-microglobulin + hMHC I + T cell receptor
    
  • 3qq3, 3qq4, 5h94 - β-2-microglobulin + MHC I + peptide - pig
    
  • 4gkn - β-2-microglobulin + MHC I + peptide – gorilla
    
  • 5f1n - β-2-microglobulin + MHC I + peptide – dog
    
  • 4zuw, 4zuv, 4zuu, 4zut, 4zus - β-2-microglobulin + MHC I + peptide – horse
    
  • 4zfz - β-2-microglobulin + MHC I + peptide – rhesus macaque
    
  • 5h5z - gcβ-2-microglobulin + MHC I + peptide
    
  • 1nez - mβ-2-microglobulin + mMHC I + CD8 α chain
• B2M in ternary complex with CD1
  • 3qux, 3quy, 3quz, 3o8x, 3o9w, 4mng, 3qi9, 3scm, 3sda, 3sdc, 3ta3, 3tn0, 3to4, 3tvm, 3sdd, 4elm, 3rtq, 3rzc, 4ei5, 4apq, 4zak, 4y4k, 4y4h, 4y4f, 4y2d, 4y16 - mβ-2-microglobulin + T cell receptor + CD1D1
    
  • 2po6, 3vwj, 3vwk, 4en3, 3sdx, 3tzv, 4lhu, 4ww2 - hβ-2-microglobulin + T cell receptor + CD1D1
    
  • 4x6c, 4x6d - hβ-2-microglobulin + T cell receptor + CD1A
    
  • 5l2k - hβ-2-microglobulin + T cell receptor + CD1B
    
  • 3dbx - cβ-2-microglobulin + CD1-2 + fatty acid
    
  • 1zhn - mβ-2-microglobulin + CD1D1 + phosphatidylcholine
    
  • 1zt4 - mβ-2-microglobulin + CD1D1 + ceramide derivative
    
  • 3ubx, 4irj, 4irs - mβ-2-microglobulin + FAB + CD1D1
    
  • 5fkp, 5efi - mβ-2-microglobulin + CD1D1 + peptide
    
  • 1xz0 - hβ-2-microglobulin + CD1A + lipopeptide
    
  • 1onq - hβ-2-microglobulin + CD1A + sulfatide
    
  • 4x6f - hβ-2-microglobulin + CD1A + sphingomyelin
    
  • 1uqs - hβ-2-microglobulin + CD1B + glycolipid
    
  • 1gzp, 1gzq - hβ-2-microglobulin + CD1B + ceramide derivative
    
  • 4ei5 - mβ-2-microglobulin + CD1D1 + T cell receptor
• B2M in ternary complex with other molecules
  • 1i1a, 1frt - rβ-2-microglobulin + Fc receptor + Fc fragment
    
  • 1de4 - hβ-2-microglobulin + hemochromatosis protein + transferring receptor
    
  • 3m17, 3m1b - hβ-2-microglobulin + FcRn+ peptide
    
  • 4k71, 4n0f, 4n0u - hβ-2-microglobulin + serum albumin + Igg receptor P51
    
• B2M in quaternary complex with MHC
  • 3qdg, 3qdj, 3qdm, 3qeq, 3mv7, 3mv8, 3mv9, 3h9s, 3gsn, 3d39, 3d3v, 3ffc, 2vlj, 2vlk, 2vll, 2vlr, 2j8u, 2p5e, 2p5w, 2pye, 2gj6, 2f54, 2esv, 2bnq, 2bnr, 1lp9, 1oga, 1mi5, 1qrn, 2nx5, 2ak4, 1qse, 1qsf, 1bd2, 1ao7, 2ypl, 4g8g, 4g9f, 4jrx, 4jry, 5jhd, 5swz, 5sws, 5isz, 5hyj, 5euo, 5eu6, 5e9d, 5e6i, 3sjv, 5d2l, 5c0c, 5c0b, 5c0a, 5c09, 5c08, 5c07, 5bs0, 5brz, 5jzi - hβ-2-microglobulin + hMHC I α + T cell receptor + peptide
    
  • 3kxf, 3mv8, 2jcc, 2uwe - hβ-2-microglobulin + hMHC I α (mutant) + T cell receptor + peptide
    
  • 5d2n - hβ-2-microglobulin + hMHC I α + C25 + peptide
    
  • 2f53 - hβ-2-microglobulin (mutant) + hMHC I α + T cell receptor + peptide
    
  • 1p7q, 1im9 - hβ-2-microglobulin + hMHC I α + leukocyte immunoglobulin-like receptor + peptide
    
  • 2dyp - hβ-2-microglobulin + hMHC I α (mutant) + leukocyte immunoglobulin-like receptor + peptide
    
  • 3qzw, 3dmm, 1bqh, 1akj - hβ-2-microglobulin + hMHC I α + CD8 α + peptide
    
  • 1im3 - hβ-2-microglobulin + hMHC I α + cytomegalovirus protein US2 + peptide
    
  • 3cii, 3cdg - hβ-2-microglobulin + hMHC I α + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide
    
  • 3hae, 3gjf, 3cvh, 1w72 - hβ-2-microglobulin + hMHC I α + antibody + peptide
    
  • 1g6r, 2ckb, 3pqy, 2z31, 1nam, 1mwa, 1g6r, 2ckb, 2ol3, 1kj2, 1kj3, 1fo0 - mβ-2-microglobulin + mMHC I + T cell receptor + peptide
    
  • 2oi9, 3rgv, 3c8k - mβ-2-microglobulin + mMHC I (mutant) + T cell receptor + peptide
    
  • 1p1z, 1p4l, 1qo3, 1efx - mβ-2-microglobulin + mMHC I + T cell receptor + peptide
    
  • 3o4l - hβ-2-microglobulin +MHC I + BSLF2/BMLF1 + T cell receptor
    
  • 4mnq - hβ-2-microglobulin +MHC I + telomerse reverse transcriptase + T cell receptor
    
  • 4eup, 4jfd, 4jfe, 4jff, 4jfo, 4jfp, 4jfq - hβ-2-microglobulin +MHC I + JKF6 + melanoma peptide
    
  • 4ftv - hβ-2-microglobulin +MHC I + A6 + protein TAX-1 peptide
    
  • 4wuu - hβ-2-microglobulin + MHC I + ESK1 + immunoglobulin heavy chain + peptide
    
  • 3hg1 - hβ-2-microglobulin +MHC I + cancer/MART-1+ T cell receptor
    
  • 4mji, 4prp, 4qok, 4qrp, 4qrr - hβ-2-microglobulin +MHC I + peptide+ T cell receptor
    
  • 3gjf - hβ-2-microglobulin + hMHC I + antibody + peptide
    
  • 3qfj - hβ-2-microglobulin + hMHC I + A6 + peptide
    
  • 4e5x, 5iro - hβ-2-microglobulin + hMHC I + E3 glycoprotein + peptide
    
  • 4hkj - hβ-2-microglobulin + hMHC I + CPXV203 protein + peptide
    
  • 4m8v, 3wuw, 4n8v, 4no0, 5t70, 5t6z, 5t6y, 5t6x, 5t6w, 5b39, 5b38 - hβ-2-microglobulin + hMHC I + killer cell Igg-like receptor + peptide
    
  • 5j6g - mβ-2-microglobulin + hMHC I + killer cell lectin-like receptor 3 + peptide
    
  • 4l3e - hβ-2-microglobulin +MHC I + DMF5 + peptide
    
• B2M in quaternary complex with CD1
  • 2q7y - mβ-2-microglobulin + CD1D1 + ceramide derivative + fatty acid
    
  • 3arb, 3ard, 3are, 3arf, 3arg, 3he6, 3he7, 3huj - mβ-2-microglobulin + T cell receptor NKT + CD1D1 + ceramide derivative
    
  • 3rug - mβ-2-microglobulin + CD1D1 + VALPHA10-Vβ8
• B2M in quaternary complex with other molecules
  • 3d2u - hβ-2-microglobulin + UL18 + leukocyte immunoglobulin-like receptor + peptide
    

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Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman