1j7v

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HUMAN IL-10 / IL-10R1 COMPLEX

Structural highlights

1j7v is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL10_HUMAN Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1). This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur. Here we report the 2.9 A crystal structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The complex consists of two IL-10s and four sIL-10R1 molecules. Several residues in the IL-10/sIL-10R1 interface are conserved in all IL-10 homologs and their receptors. The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10.

Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.,Josephson K, Logsdon NJ, Walter MR Immunity. 2001 Jul;15(1):35-46. PMID:11485736[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations
35 reviews cite this structure
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Ouyang et al. (2011)
34 more
76 other articles
No citations found

See Also

References

  1. ↑ Josephson K, Logsdon NJ, Walter MR. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 2001 Jul;15(1):35-46. PMID:11485736

Contents


PDB ID 1j7v

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OCA

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