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X-ray structure of the entire human Argonaute2 protein complex with RNA (red) (PDB 4ola) at 2.3Å resolution

External Resources

Uniprot: Q9UKV8

Wikipedia: Piwi Proteins

Wikipedia: Argonaute Proteins

Animation showing the function of Argonaute during RNA interference


  1. 1.0 1.1 1.2 Schirle NT, Macrae IJ. The Crystal Structure of Human Argonaute2. Science. 2012 Apr 26. PMID:22539551 doi:10.1126/science.1221551
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  5. Lingel A, Simon B, Izaurralde E, Sattler M. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature. 2003 Nov 27;426(6965):465-9. Epub 2003 Nov 16. PMID:14615801 doi:10.1038/nature02123
  6. Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol. 2005 Apr;12(4):340-9. Epub 2005 Mar 30. PMID:15800637 doi:10.1038/nsmb918
  7. Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science. 2004 Sep 3;305(5689):1434-7. Epub 2004 Jul 29. PMID:15284453 doi:10.1126/science.1102514

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Michal Harel, João Rodrigues, Joel L. Sussman, Alexander Berchansky

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