Argonaute

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X-ray structure of the entire human Argonaute2 protein complex with RNA (red) (PDB 4ola) at 2.3Å resolution

Drag the structure with the mouse to rotate

External Resources

Uniprot: Q9UKV8

Wikipedia: Piwi Proteins

Wikipedia: Argonaute Proteins

Animation showing the function of Argonaute during RNA interference

References

  1. 1.0 1.1 1.2 Schirle NT, Macrae IJ. The Crystal Structure of Human Argonaute2. Science. 2012 Apr 26. PMID:22539551 doi:10.1126/science.1221551
  2. Hock J, Meister G. The Argonaute protein family. Genome Biol. 2008;9(2):210. Epub 2008 Feb 26. PMID:18304383 doi:10.1186/gb-2008-9-2-210
  3. Iosue I, Quaranta R, Masciarelli S, Fontemaggi G, Batassa EM, Bertolami C, Ottone T, Divona M, Salvatori B, Padula F, Fatica A, Lo-Coco F, Nervi C, Fazi F. Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells. Cell Death Dis. 2013 Nov 21;4(11):e926. PMID:24263100 doi:10.1038/cddis.2013.452
  4. Chalertpet K, Pin-On P, Aporntewan C, Patchsung M, Ingrungruanglert P, Israsena N, Mutirangura A. Argonaute 4 as an Effector Protein in RNA-Directed DNA Methylation in Human Cells. Front Genet. 2019 Jul 4;10:645. PMID:31333722 doi:10.3389/fgene.2019.00645
  5. Yu Y, Ji L, Le BH, Zhai J, Chen J, Luscher E, Gao L, Liu C, Cao X, Mo B, Ma J, Meyers BC, Chen X. Correction: ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. PLoS Biol. 2021 Feb 11;19(2):e3001120. PMID:33571183 doi:10.1371/journal.pbio.3001120
  6. Ma JB, Ye K, Patel DJ. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature. 2004 May 20;429(6989):318-22. PMID:15152257 doi:10.1038/nature02519
  7. Gu S, Jin L, Huang Y, Zhang F, Kay MA. Slicing-Independent RISC Activation Requires the Argonaute PAZ Domain. Curr Biol. 2012 Aug 21;22(16):1536-42. Epub 2012 Jul 12. PMID:22795694 doi:10.1016/j.cub.2012.06.040
  8. Lingel A, Simon B, Izaurralde E, Sattler M. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature. 2003 Nov 27;426(6965):465-9. Epub 2003 Nov 16. PMID:14615801 doi:10.1038/nature02123
  9. Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol. 2005 Apr;12(4):340-9. Epub 2005 Mar 30. PMID:15800637 doi:10.1038/nsmb918
  10. Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. Crystal structure of Argonaute and its implications for RISC slicer activity. Science. 2004 Sep 3;305(5689):1434-7. Epub 2004 Jul 29. PMID:15284453 doi:10.1126/science.1102514

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