Cytochrome P450 hydroxylase

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Function

Cytochrome P450 hydroxylase (CPH) acts in the in-chain hydroxylation of lauric acid which is required for the development of the male organ in higher plants[1]. CPH hydroxylyzes the anti-cholesterol natural product herbosidiene[2].

See also Cytochrome P450 and Hemeproteins.

  • Lauric acid binding site.
  • Heme group binding site.
  • Fe coordination site.
  • Distances between Lauric acid oxygens and heme group Fe in Cytochrome P450 hydroxylase from Steptomyces avermitilis (PDB code 5cwe).

3D Structures of cytochrome P450 hydroxylase

Cytochrome P450 hydroxylase 3D structures


Cytochrome P450 hydroxylase containing heme complex with lauric acid, sulfate and glycerol (PDB code 5cwe)

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References

  1. Yang X, Wu D, Shi J, He Y, Pinot F, Grausem B, Yin C, Zhu L, Chen M, Luo Z, Liang W, Zhang D. Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine. J Integr Plant Biol. 2014 Oct;56(10):979-94. doi: 10.1111/jipb.12212. Epub 2014, Jul 15. PMID:24798002 doi:http://dx.doi.org/10.1111/jipb.12212
  2. Yu D, Xu F, Shao L, Zhan J. A specific cytochrome P450 hydroxylase in herboxidiene biosynthesis. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4511-4514. doi:, 10.1016/j.bmcl.2014.07.078. Epub 2014 Aug 6. PMID:25139567 doi:http://dx.doi.org/10.1016/j.bmcl.2014.07.078

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