Lipid metabolism
From Proteopedia
Under development!!!
Contents |
Lipid biosynthesis
- Fatty acid synthesis
- Acyl carrier protein
- Acyl carrier protein synthase
- Enoyl-Acyl-Carrier Protein Reductase
- InhA is an NADH dependent trans enoyl-acyl ACP carrier protein
- Fatty acid synthase
- Insulin increases fat synthesis in adipocytes.
Breakdown of lipids
Lipase
- Molecular Playground/Pancreatic Lipase
- Lipase lid morph
- Hormone sensitive lipase
- Lipase from Candida antarctica in closed state
- Monoglyceride lipase
- Human gastric lipase
- Lipase (Hebrew)
- Galactosylceramidase
Saposin
Citric Acid Cycle is the second of three stages of cellular respiration, in which glucose, Fatty Acids and certain amino acids, the so-called fuel molecules, are oxidized
Peroxisome Proliferator-Activated Receptors
The Peroxisome Proliferator-Activated Receptors (PPAR) α, γ, and δ are members of the nuclear receptor family. Since their discovery in the early 90s, it has become clear that the PPARs are essential modulators of external stimuli, acting as transcription factors to regulate mammalian metabolism, cellular differentiation, and tumorigenesis. The PPARs are the targets of numerous pharmaceutical drugs aimed at treating hypolipidemia and diabetes among other diseases.
- PPARα regulates the expression of genes involved in fatty acid β oxidation[1].
- PPARγ regulates the expression of genes involved a variety of physiological processes like development of adipose cells, cell proliferation, macrophage function and immunity[2]. For details see PPAR-gamma. For details on PPARγ drugs see Pioglitazone.
- PPARδ regulates the expression of genes involved in fatty acid burning in adipose tissue and skeletal muscle[3].
References
- ↑ van Raalte DH, Li M, Pritchard PH, Wasan KM. Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm Res. 2004 Sep;21(9):1531-8. PMID:15497675
- ↑ Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem. 2008;77:289-312. doi: 10.1146/annurev.biochem.77.061307.091829. PMID:18518822 doi:http://dx.doi.org/10.1146/annurev.biochem.77.061307.091829
- ↑ Lagathu C, Kim M, Maachi M, Vigouroux C, Cervera P, Capeau J, Caron M, Bastard JP. HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo. Biochimie. 2005 Jan;87(1):65-71. PMID:15733739 doi:http://dx.doi.org/10.1016/j.biochi.2004.12.007