Phosphoinositide phosphatase

From Proteopedia

Function Phosphoinositide phosphatase degrades phosphoinositide signals[1]. PTEN is phosphatidylinositol 3,4,5-triphosphate 3-phosphatase and dual-specificity protein phosphatase. For details of PTEN phosphatase see PTEN PTEN function PTEN (Hebrew) Disease Mutations in the Sac phosphatase lead to degenerative neuropathy[2]. Structural highlights The substrate binds to one terminus of the β sandwich. Alpha Helices,  Beta Strands ,  Loops , Turns. Substrate phosphoinositol 4-phospate binding site. Water molecules are shown as red spheres. Mg+2 coordination site. Cl- coordination site (PDB code 3mtc).[3]

spinqualitylabelsall models Human 5PTase complex with phosphoinositol 4-phospate, glycerol, sulfate, Cl- (green) and Mg+2 (light green) ions (PDB code 3mtc) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of phosphoinositide phosphatase

Updated on 04-August-2019

Phosphoinositide phosphatase

1d5r – hPTEN (mutant) – human

3rgo – mPTEN – mouse

3rgq – mPTEN + PI(5)P

3lwt – ySac1 – yeast

4tu3 – ySac1 + Vps74

4xuu – hSac2

Phosphoinositide 5-phosphatase

3n9v – h5PTase

3mtc – h5PTase + phosphatidylinositol 4-phosphate

4cml – h5PTase + phosphatidylinositol 3,4-bisphosphate

5a7i – h5PTase + biphenyl hexakisphosphate

5a7j – h5PTase + benzyl tetrakisphosphate

2kig – m5PTase

References

1. ↑ Dyson JM, Fedele CG, Davies EM, Becanovic J, Mitchell CA. Phosphoinositide phosphatases: just as important as the kinases. Subcell Biochem. 2012;58:215-79. doi: 10.1007/978-94-007-3012-0_7. PMID:22403078 doi:http://dx.doi.org/10.1007/978-94-007-3012-0_7
2. ↑ Liu Y, Bankaitis VA. Phosphoinositide phosphatases in cell biology and disease. Prog Lipid Res. 2010 Jul;49(3):201-17. doi: 10.1016/j.plipres.2009.12.001. Epub, 2010 Jan 5. PMID:20043944 doi:http://dx.doi.org/10.1016/j.plipres.2009.12.001
3. ↑ Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, Hammarstrom M, Berglund H, Nordlund P. Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases. Structure. 2014 Apr 2. pii: S0969-2126(14)00073-2. doi:, 10.1016/j.str.2014.01.013. PMID:24704254 doi:http://dx.doi.org/10.1016/j.str.2014.01.013