Phospholipase A2 homolog

From Proteopedia

Function Phospholipase A2 homolog or Basic phospholipase A2 homolog is a snake venom with phospholipase A2 (PLA2) sequence homology and structure homology which has almost no PLA2 activity, i.e., cleaving of fatty acids. The loss of PLA2 catalytic activity is due to the substitution of the conserved Asp49 in the active site by Lys49 in the homolog[1]. Disease The venom causes severe muscle necrosis. Structural highlights The complex between PLA2 homolog and the inhibitor suramin shows the inhibitor interacting with both monomers. The water molecules are shown as red spheres. The location of PLA2 active site conserved Asp49 which is substituted by Lys in PLA2 homologs thus rendering PLA2[2].

Jmol._Canvas2D (Jmol) "jmolApplet1"[x] spinqualitylabelsall models Phospholipase A2 homolog dimer complex with inhibitor suramin, PEG400, pentaethylene glycol and sulfate (PDB code 4yv5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of phospholipase A2 homolog

Updated on 21-July-2024

Phospholipase A2 homolog

1s8i, 1s8h - bbcMyotoxin - broad-banded copperhead

1s8g - bbcMyotoxin + fatty acid

4h0s - CTS-R6 - chinese green tree viper

3vbz, 3vc0 - taipoxin β subunit - Australian taipan

4nty, 4ntw - tcsMITTX + ASIC1 + neurotoxin - Texas coral snake

4ntx - tcsMITTX + ASIC1 + neurotoxin + amiloride

2ph4 - Zhaoermiatoxin - Zhaoermia mangshanensis

1mc2 - Acutohaemolysin - chinese moccasin

Phospholipase A2 homolog 1

3t0r - lhvMyotoxin I - lance-headed viper

6ce2 - BmMyotoxin I + suramin - Bothrops moojeni

7lye - BmMyotoxin I + inhibitor

2ok9, 2q2j - plhPiratoxin I - Piraja's lance head

3qnl - plhPiratoxin I + rosmarinic acid

4yu7 - plhPiratoxin I + caffeic acid

4yz7 - plhPiratoxin I + aristolochic acid

3cyl - plhPiratoxin I + α-tocopherol

Phospholipase A2 homolog 2

6pwh - lhvMyotoxin II

2aoz - Myotoxin II - Atropoides nummifer

6b84, 4kf3 - BmMyotoxin II

6b81 - BmMyotoxin II + caprylic acid

6b83 - BmMyotoxin II + caproic acid

6mqd - BmMyotoxin II + rosmarinic acid

1xxs - BmMyotoxin II + stearic acid

6b80 - BmMyotoxin II + myristic acid

6mqf - BmMyotoxin II + acetylsalicylic acid

4yv5 - BmMyotoxin II + suramin

1clp - BaMyotoxin II - Bothrops asper

1y4l - BaMyotoxin II + suramin

5vfh, 1pa0 - nlBnsp-7 - neuwid's lancehead

5vfn - nlBnsp-7 + cinnamic acid

5vfm - nlBnsp-7 + coumaric acid

5vfj - nlBnsp-7 + caffeic acid

1pc9 - nlBnsp-6

3qll - plhPiratoxin II

3god - Godmt II - Cerrophidion godmani

Phospholipase A2 homolog bothropstoxin

3i3h, 3i3i, 3hzd, 3iq3, 4wtb, 2h8i - BjBTXTX-I - Bothrops jararacussu

3i03, 3hzw - BjBTXTX-I + bromophenacyl bromide

6dik - BjBTXTX-I + chicoric acid

3cxi - BjBTXTX-I + α-tocopherol

3jr8 - BjBTXTX-II

Phospholipase A2 homolog ammodytin-l

3dih - Adl - western sand viper

References

1. ↑ Lomonte B, Angulo Y, Sasa M, Gutierrez JM. The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles. Protein Pept Lett. 2009;16(8):860-76. doi: 10.2174/092986609788923356. PMID:19689412 doi:http://dx.doi.org/10.2174/092986609788923356
2. ↑ Salvador GH, Dreyer TR, Cavalcante WL, Matioli FF, Dos Santos JI, Velazquez-Campoy A, Gallacci M, Fontes MR. Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin. Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2066-78. doi:, 10.1107/S1399004715014443. Epub 2015 Sep 26. PMID:26457430 doi:http://dx.doi.org/10.1107/S1399004715014443