Serotonin Transporter

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Structure of the SERT Homologue LeuT, (2q6h)

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3D structures of serotonin transporter

Updated on 22-February-2024

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This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University.


  1. Marazziti D, Akiskal HS, Rossi A, Cassano GB. Alteration of the platelet serotonin transporter in romantic love. Psychol Med. 1999 May;29(3):741-5. PMID:10405096
  2. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996 Nov 29;274(5292):1527-31. PMID:8929413
  3. Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci. 2007 Sep;10(9):1116-24. PMID:17726478 doi:10.1038/nn1944
  4. Devlin B, Cook EH Jr, Coon H, Dawson G, Grigorenko EL, McMahon W, Minshew N, Pauls D, Smith M, Spence MA, Rodier PM, Stodgell C, Schellenberg GD. Autism and the serotonin transporter: the long and short of it. Mol Psychiatry. 2005 Dec;10(12):1110-6. PMID:16103890 doi:10.1038/
  5. Scott MM, Deneris ES. Making and breaking serotonin neurons and autism. Int J Dev Neurosci. 2005 Apr-May;23(2-3):277-85. PMID:15749252 doi:10.1016/j.ijdevneu.2004.05.012
  6. Timme M. Revealing network connectivity from response dynamics. Phys Rev Lett. 2007 Jun 1;98(22):224101. Epub 2007 May 30. PMID:17677845
  7. Hyman SE. Neuroscience: obsessed with grooming. Nature. 2007 Aug 23;448(7156):871-2. PMID:17713517 doi:10.1038/448871a
  8. Singh SK, Yamashita A, Gouaux E. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature. 2007 Aug 23;448(7156):952-6. Epub 2007 Aug 8. PMID:17687333 doi:10.1038/nature06038
  9. Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol. 2009 Jun;16(6):652-7. Epub 2009 May 10. PMID:19430461 doi:10.1038/nsmb.1602

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