Thioester protein crosslinks

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Detection and Visualization

FirstGlance in Jmol alerts you to protein crosslinks when present, and provides convenient links that zoom in and and display each one in detail. Viewing the electron density map is just one more click. Use the links above to 4-character PDB codes to go to a Proteopedia page titled with that 4-character PDB code. There, click on "FirstGlance". In FirstGlance, click on the Tools tab, and there, on "Protein Crosslinks". See the practical guide FirstGlance/Evaluating Protein Crosslinks.

Other Protein Crosslinks

In addition to the thioester bonds discussed above, other covalent cross-links between polypeptide chains include:


  1. Nakata M, Kreikemeyer B. Genetics, Structure, and Function of Group A Streptococcal Pili. Front Microbiol. 2021 Feb 9;12:616508. doi: 10.3389/fmicb.2021.616508., eCollection 2021. PMID:33633705 doi:
  2. 2.0 2.1 Miller OK, Banfield MJ, Schwarz-Linek U. A new structural class of bacterial thioester domains reveals a slipknot topology. Protein Sci. 2018 Jul 27. doi: 10.1002/pro.3478. PMID:30052296 doi:
  3. Gago-Cordoba C, Val-Calvo J, Abia D, Diaz-Talavera A, Miguel-Arribas A, Aguilar Suarez R, van Dijl JM, Wu LJ, Meijer WJJ. A Conserved Class II Type Thioester Domain-Containing Adhesin Is Required for Efficient Conjugation in Bacillus subtilis. mBio. 2021 Mar 16;12(2). pii: mBio.00104-21. doi: 10.1128/mBio.00104-21. PMID:33727345 doi:
  4. Linke-Winnebeck C, Paterson NG, Young PG, Middleditch MJ, Greenwood DR, Witte G, Baker EN. Structural model for the covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond. J Biol Chem. 2013 Nov 12. PMID:24220033 doi:

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz

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