Reverse transcriptase

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HIV-1 reverse transcriptase P66 subunit (grey) and P51 subunit (green) complex with sulfate 3dlk

See Also


References

  1. Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science. 1992 Jun 26;256(5065):1783-90. PMID:1377403 doi:[http://dx.doi.org/10.1126/science.1377403 http://dx.doi.org/10.1126/science.1377403
  2. Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. J Mol Biol. 2009 Jan 23;385(3):693-713. doi: 10.1016/j.jmb.2008.10.071. Epub 2008, Nov 3. PMID:19022262 doi:http://dx.doi.org/10.1016/j.jmb.2008.10.071
  3. ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein Function DOI: 10.1002/ijch.201200096
  4. Abbondanzieri EA, Bokinsky G, Rausch JW, Zhang JX, Le Grice SF, Zhuang X. Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature. 2008 May 8;453(7192):184-9. PMID:18464735 doi:10.1038/nature06941

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