Beta secretase

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Human β-secretase (PDB code 1w51)

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  • CambridgeJournals. <>
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  • Willem M, Dewachter I, Smyth N, Dooren TV, Borghgraef P, Haass C, Leuven FV (2004). "β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE x APP[V717I] Double-Transgenic Mice". The American Journal of Pathology 165:1621-1631.
  • Wilquet V, Strooper BD (2004). "Amyloid-beta Precursor Protein Processing in Neurodegeneration". Current Opinion in Neurobiology 14:582-588.
  • Xu, Y., Li, M., Greenblatt, H.M., Chen, W., Paz, A., Dym, O., Peleg, Y., Chen, T., Shen, X., He, J., Jiang, H., Silman, I. & Sussman, J.L. (2012). “Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations” Acta Crystallogr D Biol Crystallogr D68, 13-25.

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