Colicin E2

From Proteopedia

Jump to: navigation, search

Colicin E2 is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them with its DNase activity; it digests the host genome, leading to its death.

Synthesis and release

The ColE2 operon is encoded on a plasmid in E. coli, alongside its Colicin Immunity Protein, Imm. This protects the colicinogenic cell from the cytotoxic activity of the colicin.

Mechanism of uptake

PDB ID 2ysu

Drag the structure with the mouse to rotate
2ysu, resolution 3.50Å ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml

Colicin E2 binds to the BtuB receptor on the target E. coli cell to begin its translocation across the membrane. This structure shows the binding between (blue) and the (green). After binding to the BtuB receptor, the immunity protein is released from the cytotoxic domain prior to translocation across the membrane.

Killing Activities

Colicin E2 kills its target cell, after leaving behind the immunity protein at the cell surface, with its DNase Activity found in its C terminal cytotoxic domain.

Proteopedia Page Contributors and Editors (what is this?)

Gemma McGoldrick

Personal tools