DNase Activity

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Many Colicins exhibit enzymatic DNase activity as their cytotoxic activity to kill the targeted E. coli cell. The structure shows the DNase domain of Colicin E9 bound to its Colicin Immunity Protein, Im9. These kill the cell by selectively cleaving the DNA throughout the genome, which ultimately leads to cell death as the damage is too great for the cell to repair itself. Rather than continue to live with a faulty genome, the cell kills itself.

This shows just the DNase domain, as bound to Im9. Here instead shows just the immunity protein.


PDB ID 2k5x

Drag the structure with the mouse to rotate
2k5x, 1 NMR models ()
Gene: imm, ceiE9 (Escherichia coli), col, cei (Escherichia coli)
Related: 1imq, 1fsj, 1emv
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Colicins with DNase activity

Colicin E2
Colicin E7
Colicin E8
Colicin E9

3D structures of colicin

Colicin

Proteopedia Page Contributors and Editors (what is this?)

Gemma McGoldrick, Michal Harel

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