Colicin Immunity Protein

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Colicin-E9 immunity protein (grey) complex with colicin-E7 (pink) and Zn+2 ion (grey) (PDB code 3gkl)

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  1. Meenan NA, Sharma A, Fleishman SJ, Macdonald CJ, Morel B, Boetzel R, Moore GR, Baker D, Kleanthous C. The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction. Proc Natl Acad Sci U S A. 2010 May 17. PMID:20479265
  2. Li C, Zhao D, Djebli A, Shoham M. Crystal structure of colicin E3 immunity protein: an inhibitor of a ribosome-inactivating RNase. Structure. 1999 Nov 15;7(11):1365-72. PMID:10574790
  3. Yajima S, Inoue S, Ogawa T, Nonaka T, Ohsawa K, Masaki H. Structural basis for sequence-dependent recognition of colicin E5 tRNase by mimicking the mRNA-tRNA interaction. Nucleic Acids Res. 2006;34(21):6074-82. Epub 2006 Nov 11. PMID:17099236 doi:10.1093/nar/gkl729
  4. Ko TP, Liao CC, Ku WY, Chak KF, Yuan HS. The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein. Structure. 1999 Jan 15;7(1):91-102. PMID:10368275
  5. Montalvao RW, Cavalli A, Salvatella X, Blundell TL, Vendruscolo M. Structure Determination of Protein-Protein Complexes Using NMR Chemical Shifts: Case of an Endonuclease Colicin-Immunity Protein Complex. J Am Chem Soc. 2008 Nov 4. PMID:18980319 doi:10.1021/ja805258z
  6. Graille M, Mora L, Buckingham RH, van Tilbeurgh H, de Zamaroczy M. Structural inhibition of the colicin D tRNase by the tRNA-mimicking immunity protein. EMBO J. 2004 Apr 7;23(7):1474-82. Epub 2004 Mar 11. PMID:15014439 doi:10.1038/sj.emboj.7600162
  7. Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS. Following evolutionary paths to protein-protein interactions with high affinity and selectivity. Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. Epub 2009 Sep 13. PMID:19749752 doi:10.1038/nsmb.1670

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