Follicle-stimulating hormone

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Contents

Function

Follicle-stimulating hormone (FSH) is secreted by the anterior pituitary gland. FSH regulates development, growth and pubertal maturation of the human body[1].

For details see

Human Follicle-Stimulating Hormone Complexed with its Receptor
Leucine-rich repeat
FSH (Hebrew).

See also Hormone.

Relevance

FSH level is measured by a blood test in order to evaluate various infertility and menopause problems.

3D structures of follicle-stimulating hormone

Updated on 06-March-2023

1fl7 – hFSH – human

1xwd – hFSH + a significant portion of the FSH receptor extracellular domain
4ay9 – hFSH + the entire FSH receptor extracellular domain
4mqw – hFSH β + FSH receptor + glycoprotein hormone

References

  1. ↑ Pierce JG, Parsons TF. Glycoprotein hormones: structure and function. Annu Rev Biochem. 1981;50:465-95. PMID:6267989 doi:http://dx.doi.org/10.1146/annurev.bi.50.070181.002341

Human glycosylated FSH α chain (cyan, pink), β chain (green, yellow) complex with sulfate (PDB entry 1fl7)

Drag the structure with the mouse to rotate

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Michal Harel, Joel L. Sussman, Alexander Berchansky, Wayne Decatur

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