Major capsid protein L1

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The L1 major capsid protein comprises the majority of Gardasil 9 (PDB code 2r5h)

3D structures of major capsid protein L1

Updated on 24-October-2021

3iyj – MCP – bovine papilloma virus 1 – Cryo EM
6l31 – Hpv6MCP – human papilloma virus 6 – Cryo EM
2r5k – Hpv11MCP – human papilloma virus 11
2r5h – Hpv16MCP – human papilloma virus 16
3j7g, 3j6r, 5kep, 5keq, 5bsp, 6bt3, 7kzf – Hpv16MCP – Cryo EM
1dzl – Hpv16MCP (mutant) – Cryo EM
3j8v, 3j8w, 3j8z, 3jba, 6bsp, 7cn2 – Hpv16MCP + antibody – Cryo EM
5w1o – Hpv16MCP + heparin
2r5i – Hpv18MCP – human papilloma virus 18
5w1x – Hpv18MCP (mutant) + heparin
6ige – Hpv33MCP (mutant) – human papilloma virus 33
2r5j – Hpv35MCP – human papilloma virus 35
6igf – Hpv52MCP – human papilloma virus 52
6igc, 6igd, 5y9e – Hpv58MCP – human papilloma virus 58
7dn5 – Hpv58MCP – Cryo EM
5y9c – Hpv58MCP + antibody
7dnh, 7dnk, 7dnl – Hpv58MCP + antibody – Cryo EM
5j6r – Hpv59MCP (mutant) – human papilloma virus 59
5jb1 – Hpv59MCP – Cryo EM
5y9f – Hpv59MCP + antibody

References

  1. name="mcp>PMID:23800545
  2. 2.0 2.1 Zhai L, Tumban E. Gardasil-9: A global survey of projected efficacy. Antiviral Res. 2016 Jun;130:101-9. doi: 10.1016/j.antiviral.2016.03.016. Epub, 2016 Apr 1. PMID:27040313 doi:http://dx.doi.org/10.1016/j.antiviral.2016.03.016
  3. https://www.gardasil9.com
  4. 4.0 4.1 http://www.hpvvaccine.org.au/the-hpv-vaccine/how-does-it-work.aspx
  5. 5.0 5.1 https://www.medicines.org.uk/emc/medicine/19016
  6. Harper DM, Vierthaler SL, Santee JA. Review of Gardasil. J Vaccines Vaccin. 2010 Nov 23;1(107). pii: 1000107. PMID:23805398 doi:http://dx.doi.org/10.4172/2157-7560.1000107
  7. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000703/WC500021140.pdf
  8. Finnen RL, Erickson KD, Chen XS, Garcea RL. Interactions between papillomavirus L1 and L2 capsid proteins. J Virol. 2003 Apr;77(8):4818-26. PMID:12663788
  9. Cite error: Invalid <ref> tag; no text was provided for refs named mcp
  10. http://www.uniprot.org/uniprot/P03101
  11. https://www.merck.com/product/usa/pi_circulars/g/gardasil/gardasil_ppi.pdf
  12. Caulfield MJ, Shi L, Wang S, Wang B, Tobery TW, Mach H, Ahl PL, Cannon JL, Cook JC, Heinrichs JH, Sitrin RD. Effect of alternative aluminum adjuvants on the absorption and immunogenicity of HPV16 L1 VLPs in mice. Hum Vaccin. 2007 Jul-Aug;3(4):139-45. Epub 2007 Apr 5. PMID:17581283
  13. http://www.fda.gov/BiologicsBloodVaccines/Vaccines/QuestionsaboutVaccines/ucm096052.htm
  14. http://www.news-medical.net/health/Histamine-Storage-and-Release.aspx
  15. www.westonaprice.org/health-topics/vaccination/adjuvants-in-vaccines/
  16. http://www.immune.org.nz/sites/default/files/resources/ConcernVaccineIngredients20140522V01Final.pdf
  17. 17.0 17.1 17.2 Murray, Patrick R., Ken S. Rosenthal, and Michael A. Pfaller. "Papillomavirus and Polyomavirus." Medical Microbiology. Philadelphia: Elsevier/Saunders, 2013. 445-450.
  18. http://www.kegel.com/hpv/deaths/

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